Novel one-pot four-component condensation cyclization reactions for the synthesis of thiazolidine-4-one and 3H-thiazoles

ABSTRACT

A novel, simple and efficient synthetic protocol has been developed for the synthesis of a series of thiazolidine-4-one and 3H-thiazole derivatives via a one-pot four-component condensation-cyclization reaction of hydrazine with allyl isothiocyanate and an α-haloketone in the presence of various aldehydes. This new protocol produces novel thiazolidine-4-one and 3H-thiazole derivatives in excellent yields. The remarkable features of this methodology are high yields, easy work-up and a one-pot simple reaction method.

GRAPHICAL ABSTRACT

KEYWORDS:

• Heterocycles
• multicomponenet reaction
• sulfur
• thiazolidine-4-one
• 3H-thiazole

Disclosure statement

No potential conflict of interest was reported by the authors.

Acknowledgements

The authors gratefully acknowledge support by the Institute for Advanced Studies in Basic Sciences (IASBS) Research Council.

Additional information

Funding

This work was supported by Iran National Science Foundation (INSF) major project (Grant No. 93048780) and Postdoc programs of Institute Advanced Studies Basic Science-Zanjan (Iran).