Synthesis of new 2-amino-4H-thiopyran derivatives via the one-pot reaction between 3,4-dihydro-3-((benzylamino)methylene)-4-thioxochromen-2-ones and alkyl-2-cyanoacetates in the presence of nano-ZnO catalysis

ABSTRACT

One-pot reaction between 3,4-dihydro-3-((benzylamino)methylene)-4-thioxochromen-2-ones and alkyl-2-cyanoacetates in the presence of an excess amount of triethylamine and a catalytic amount of nano-ZnO particles in acetonitrile leads to new 2-amino-4H-thiopyran derivatives in high to excellent yields within 15 min.

GRAPHICAL ABSTRACT

KEYWORDS:

• Ethyl-2-cyanoacetate
• zinc oxide nanoparticles
• 2-amino-4H-thiopyran
• MCR
• one-pot reaction

Disclosure statement

No potential conflict of interest was reported by the author(s).