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Editorial

Antiretroviral drug-loaded nanoparticles-in-films: a new option for developing vaginal microbicides?

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Pages 449-452 | Received 26 Oct 2016, Accepted 06 Dec 2016, Published online: 14 Dec 2016

Figures & data

Figure 1. Selected features of TFV/EFV-NPs-in-film. (a) Photograph and (b, c) SEM micrographs (surface and exposed side sections after fracture; bars = 50 µm) of TFV/EFV-NPs-in-film. (d) EFV release profile in simulated vaginal fluid from TFV/EFV-film, EFV-NPs (i.e., without being incorporated into film) and TFV/EFV-NPs-in-film. Relevantly, almost half of the drug content was released within 1 h, which could provide a burst dose for immediate protection, while continuously drug release up to 24 h may aid sustaining protection. Points and vertical bars in drug release profiles represent mean values and standard deviations, respectively (n = 3). Please note the square root of time in the x-axis. Modified from [Citation14], Copyright (2016), with permission from Elsevier.

Figure 1. Selected features of TFV/EFV-NPs-in-film. (a) Photograph and (b, c) SEM micrographs (surface and exposed side sections after fracture; bars = 50 µm) of TFV/EFV-NPs-in-film. (d) EFV release profile in simulated vaginal fluid from TFV/EFV-film, EFV-NPs (i.e., without being incorporated into film) and TFV/EFV-NPs-in-film. Relevantly, almost half of the drug content was released within 1 h, which could provide a burst dose for immediate protection, while continuously drug release up to 24 h may aid sustaining protection. Points and vertical bars in drug release profiles represent mean values and standard deviations, respectively (n = 3). Please note the square root of time in the x-axis. Modified from [Citation14], Copyright (2016), with permission from Elsevier.

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