Figures & data
Table 1. Frequencies of the modalities used to instigate triggered release.
Table 2. Description of clinical trials discussed in section 6 along with their identifier number, status of the study, date of publication, drug used, disease targeted and heating modality as of January 2022, all trials involved the delivery of the drug dox.
Figure 1. Mechanism of action of thermosensitive liposomes under hyperthermia. The green lining is showing lipid shell whereas drug is represented by yellow color (a). Firstly, liposomes pass through the leaky blood vessels, potentially by EPR effect (b). The big red circle is showing region of applied hyperthermia. Hyperthermia increases the vessel pore size and liposomal extravasation is increased too(c). Drug is probably released in tumor interstitium, in addition vasculature (d) and cell membrane permeability may also be increased, adapted from [Citation42].
![Figure 1. Mechanism of action of thermosensitive liposomes under hyperthermia. The green lining is showing lipid shell whereas drug is represented by yellow color (a). Firstly, liposomes pass through the leaky blood vessels, potentially by EPR effect (b). The big red circle is showing region of applied hyperthermia. Hyperthermia increases the vessel pore size and liposomal extravasation is increased too(c). Drug is probably released in tumor interstitium, in addition vasculature (d) and cell membrane permeability may also be increased, adapted from [Citation42].](/cms/asset/d3492b0e-5a16-4d4e-9029-94ba1c182fab/iedd_a_2099834_f0001_oc.jpg)
Figure 2. Mechanism of microwave induced heating.
