The role of OATP1B1 and OATP1B3 transporter polymorphisms in drug disposition and response to anticancer drugs: a review of the recent literature

Figures & data

Figure 1. Overview of covered topics.

Table 1. Characteristics of each SLCO1B1 and SLCO1B3 single nucleotide polymorphisms (SNPs) discussed in this review.

	RS Number	Nucleotide Change [90]	Amino Acid Change	Reading Frame Change	Location	Exon	Allele Frequency (Global)		Known Functional Impact (in vitro)	Clinical Effect	References
							Reference	Alternative
OATP1B1	rs4149056	c.521 T > C	p.V174A	V [GTG] > A [GCG]	chr12:21,178,615 (GRCh38.p13)	5	T = 0.850467	C = 0.149533	Decreased	Altered Response to simvastatin, rosuvastatin, pravastatin, hmg coa reductase inhibitors, methotrexate, anthracyclines, regorafenib, exemestane, and cerivastatin	[90,91] References cited in main text,
	rs2306283	c.388A>G	p.N130D	N [AAT] > D [GAT]	chr12:21,176,804 (GRCh38.p13)	4	A = 0.568618	G = 0.431382	Decreased/unchanged	Rotor’s Syndrome, Gilbert’s Syndrome, Altered Response to Methotrexate
	rs11045879	c.1865 + 4846 T > C	Intron Variant	NA	chr12:21,229,685 (GRCh38.p13)	NA	T = 0.829128	C = 0.170872	NA	Altered Response to Methotrexate
	rs10841753	c.85–4214 T > C	Intron Variant	NA	chr12:21,168,436 (GRCh38.p13)	NA	T = 0.806136	C = 0.193864	NA	Altered Response to Methotrexate
	***SLCO1B1*15 (Containing both rs4149056 and rs2306283)									Altered Response to Taxanes and Irinotecan
OATP1B3	rs4149117	c.334 T > G	p.S112A	S [TCT] > A [GCT]	chr12:20,858,546 (GRCh38.p13)	4	T = 0.158391	G = 0.841609	Decreased/unchanged	Rotor’s Syndrome, Gilbert’s Syndrome, Altered Response to Sunitinib	[90] References cited in main text
	rs7311358	c.699 G > A	p.M233I	M [ATG] > I [ATA]	chr12:20,862,826 (GRCh38.p13)	7	G = 0.170106	A = 0.829894	Decreased/unchanged	Rotor’s Syndrome
	rs72559743	c.1564 G > T	p.G522C	G [GGT] > C [TGT]	chr12:20,883,484 (GRCh38.p13)	12	G = 1.00000	T = 0.00000	Decreased	NA
	rs12299012	c.1679 T > C	p.V560A	V [GTG] > A [GCG]	chr12:20,883,599 (GRCh38.p13)	12	T = 0.998917	C = 0.001083	Decreased	Rotor’s Syndrome
	rs60571683	c.1977 G > A	p.S659S	S [TCG] > S [TCA]	chr12:20,916,115 (GRCh38.p13)	NA	G = 0.947403	A = 0.052597	NA	Rotor’s Syndrome
	rs11045585	VS12-5676A>G	Intron Variant	NA	chr12:20,892,760 (GRCh38.p13)	3ʹUTR	A = 0.867800	G = 0.132200	NA	NA

“Table of pharmacogenomic biomarkers in drug labeling.”

 Google Scholar

Giacomini KM, Yee SW, Ratain MJ, et al. Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med. 2012 Sep;4(153): 153-ps18.

 PubMed Web of Science ®Google Scholar