Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis

ABSTRACT

Background: Psoriatic arthritis (PsA) is a chronic skin and joint condition that considerably affects patient quality of life. Several studies have demonstrated different associations of genetic polymorphisms in the pathogenic process of PsA. Therefore, we conducted a meta-analysis to estimate the effect of polymorphisms in the cytokines TNF, IL12B, IL23A, and IL23R on PsA risk.

Methods: We screened 1,097 abstracts and identified 14 relevant studies published between January 2007 and December 2017. A systematic search was conducted in PubMed, Web of Knowledge and Scopus databases. Meta-analyses were performed for the comparisons of alleles and multiple genetic models.

Results: Among the cytokines studied, we found 17 polymorphisms that were the most investigated. The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), −308 G > A (rs1800629), and −857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026).

Conclusion: Our findings suggest that these variant cytokine genes may strongly influence the immunological response of PsA.

KEYWORDS:

• Cytokines
• meta-analysis
• polymorphism genetic
• psoriatic arthritis
• Spondylarthropathies

Acknowledgments

The authors are especially thankful to Denise Manjurma da Silva Reis for her useful comments and advice. We are also grateful to the staff of the Laboratory of Immunogenetics, to the financial support from the Laboratory of Immunogenetics - UEM (Projeto nº 00639/99-DEG-UEM), Fundação Araucária do Estado do Paraná, CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This paper was funded by the Laboratory of Immunogenetics, Universidade Estadual de Maringa, Brazil (Project no. 00639/99-DEG-UEM).