Figures & data
Figure 1. Structure and biological activities of DEL-1. Shown are the multi-domain structure of DEL-1 (central panel) as well as four major regulatory activities of this protein which impact innate and adaptive immune cell function (panels a–d, as indicated). For details, see text.The binding site of DEL-1 for LFA-1 is currently uncertain and was not indicated, although the E3 repeat is required for this interaction. DEL-1, Developmental endothelial locus-1; ECM, extracellular matrix; EGF, epidermal growth factor; FOXP3, forkhead box P3; HSC, hematopoietic stem cell; ICAM-1, intercellular adhesion molecule-1; LFA-1, lymphocyte function-associated antigen-1; PS, phosphatidyl serine; Th17, T helper 17 cell; Treg, T regulatory cell
Abbreviations:DEL-1, Developmental endothelial locus-1EAE, experimental autoimmune encephalomyelitisEDIL3, EGF-like repeats and discoidin I-like domains-3EGF, epidermal growth factorERK1/2, extracellular signal-regulated kinase1/2FAK, focal adhesion kinaseFOXP3, forkhead box P3HSC, hematopoietic stem cellICAM-1, intercellular adhesion molecule-1LFA-1, lymphocyte function-associatedantigen-1LXR, liver X receptorRUNX1, Runtrelatedtranscription factor-1RUNX2, Runtrelate transcription factor-2Th17,T helper 17Treg, regulatory T (cell)
