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Original

Local application of basic fibroblast growth factor increases the risk of local infection after trauma: An in-vitro and in-vivo study in rats

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Pages 63-73 | Received 24 Oct 2005, Accepted 03 May 2006, Published online: 08 Jul 2009

Figures & data

Figure 1. Cytokine release from PBMCs (1 × 106/mL) in the presence of exogenously added bFGF (5, 10, 100, and 200 ng/mL) after 24 h of incubation. For culture conditions, see Material and methods. Control: no exogenously added bFGF. * p < 0.05; ** p < 0.01.

Figure 1. Cytokine release from PBMCs (1 × 106/mL) in the presence of exogenously added bFGF (5, 10, 100, and 200 ng/mL) after 24 h of incubation. For culture conditions, see Material and methods. Control: no exogenously added bFGF. * p < 0.05; ** p < 0.01.

Figure 2. Infection rate related to dose of inoculum (in CFU), showing the positive results as percentages of each group. The numbers indicate the number of infected animals over the total number of animals, at each dose of inoculum.

Figure 2. Infection rate related to dose of inoculum (in CFU), showing the positive results as percentages of each group. The numbers indicate the number of infected animals over the total number of animals, at each dose of inoculum.

Figure 3. Infection rates for the groups with and without bFGF-application after soft tissue trauma in total and related to each of six experimental phases are graphically demonstrated in the upper section. The number of animals in total and in each phase is noted at the top. Inoculum doses between 1x105 CFU and 2x107 CFU were used. Below the results from each phase for either group, the inoculum doses and the number of animals used at these doses are indicated, reflecting the sequential “up-and-down” dosage technique

Figure 3. Infection rates for the groups with and without bFGF-application after soft tissue trauma in total and related to each of six experimental phases are graphically demonstrated in the upper section. The number of animals in total and in each phase is noted at the top. Inoculum doses between 1x105 CFU and 2x107 CFU were used. Below the results from each phase for either group, the inoculum doses and the number of animals used at these doses are indicated, reflecting the sequential “up-and-down” dosage technique

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