No effect of ketoprofen and meloxicam on bone graft ingrowth: A bone chamber study in goats

Figures & data

Figure 1. Example of typical bone ingrowth in a bone chamber (hematoxylin and eosin). This goat received meloxicam and a rinsed allograft was used. Nonvascular-ized remnants of the graft (G) can be seen at the top of the chamber. A fibrous ingrowth zone (F) can be seen between the graft and the newly formed bone, and a zone of newly formed bone (B) can be seen at the bottom of the chamber. Magnification 12.5x.

Figure 2. Typical histological section from a sample of a graft from a goat that received ketoprofen (hematoxylin and eosin). Newly formed woven bone (NB) in a fibrovas-cular stroma (FS) can be seen, with vital osteoblasts (*) and osteoclasts (C) surrounding the newly formed bone. Magnification 50x.

Figure 3. Typical histological section from a sample of a graft from a goat that received meloxicam (hematoxylin and eosin). New woven bone (NB) in a fibrovascular stroma (FS), with osteoblasts (*) and osteoclasts (C) comparable to the bone formation in goats that received ketoprofen. Magnification 50x.

Table 1.  Bone ingrowth and fibrous ingrowth, mm (SD)

	No medication		Ketoprofen		Meloxicam
	Bone	Tissue	Bone	Tissue	Bone	Tissue
Autograft	0.5 (0.6)	3.9 (1.1)	1.0 (1.1)	4.5 (1.6)	1.0 (1.1)	4.1 (1.2)
Allograft	0.8 (0.8)	4.1 (1.2)	1.0 (1.8)	4.2 (1.3)	1.0 (0.8)	1.0 (1.8)
Irradiated allograft	1.0 (1.0)	4.1 (1.5)	0.8 (0.7)	4.5 (1.4)	1.1 (0.9)	4.5 (1.3)

Table 2.  Bone ingrowth in the different medication groups

Medication	Difference observed, in mm	95% CIP-val	P-value
No medication vs. ketoprofen	−0.14	−0.66−0.38	0.6
	(no medication lower than ketoprofen)
No medication vs. meloxicam	−0.3	−0.82-0.22	0.2
	(no medication lower than meloxicam)
Ketoprofen vs. meloxicam	−0.16	−0.69-0.34	0.5
	(ketoprofen lower than meloxicam)

Table 3.  Tests of fixed effects; relationship between bone ingrowth and graft type, medication, side, and position of the bone chamber

	Degrees of freedom	F-value	P-value
Graft type	2	0.92	0.4
Medication	2	0.73	0.5
Side	1	0.28	0.6
Position	2	0.60	0.6