Hypertonic saline reduces skeletal muscle injury and associated remote organ injury following ischemia reperfusion injury

Figures & data

Figure 1. Effect of administration of hypertonic saline on mean peak twitch contraction in rats subjected to ischemia reperfusion injury. Data are expressed as mean (SD) for 9 rats in each group. ^ap < 0.03 for hypertonic saline (HTS) vs. normal saline.

Figure 2. Effect of administration of hypertonic saline on mean tetanic contractions in rats subjected to ischemia reperfusion injury. Data are expressed as mean (SD) for 9 rats in each group. ^ap < 0.03 for for hypertonic saline (HTS) vs. normal saline.

Skeletal muscle and lung neutrophil infiltration (myeloperoxidase activity) and edema formation (wet-to-dry-ratio). Values are expressed as mean (SD)

	Skeletal muscle		Lung
	Myeloperoxidase activity (units/g)	Wet-to-dry ratio	Myeloperoxidase activity (units/g)	Wet-to-dry ratio
Control	0.64 (0.08)	3.05 (0.10)	2.68 (0.54)	3.08 (0.12)
Normal saline	0.81 (0.07)	3.65 (0.26)	4.37 (0.23)	3.55 (0.24)
Hypertonic saline	0.73 (0.10)	3.37 (0.17)	3.83 (0.39)	3.29 (0.28)
P-value ^a	< 0.04	< 0.01	< 0.03	< 0.03

^a hypertonic saline vs. normal saline.