Blood cytokine pattern and clinical outcome in knee arthroplasty patients: comparative analysis 5 years after standard versus “hypoallergenic” surface coated prosthesis implantation

Figures & data

Figure 1 (left panel) Serum cytokine levels in patients with the uncoated (n = 98) and coated (n = 92) TKR (e.motion/e.motion-AS). (right panel) Serum cytokine levels in 20 patients prior to primary arthroplasty (“preoperative”) and 20 healthy individuals without implant (“controls”). The cytokines IL8, IL-6, the immunoregulatory IL-10, and the T-cell chemoattractant CXCL10 were assessed. Concentrations are given in pg/mL. ^b p < 0.01; ^c p < 0.001; standard deviation is given.

Figure 2 Relative expression levels of mRNA for IL-10 and IL-8 in peripheral blood of patients with the uncoated (n = 98) and coated (n = 92) TKR (e.motion/e.motion-AS). ^c p < 0.001; standard deviation is given. NS: not significant.

Characteristics of the 196 patients with primary TKR and of the 40 individuals without metal implant

	Group I uncoated ^a	Group II coated ^b	Group III preoperative ^c	Group IV healthy controls ^d
Patients	99	97	20	20
Sex (female/male)	54/45	56/41	17/3	14/6
Age median (years)	67 (44–84)	70 (48–82)	60 (46–84)	61 (52–63)
Smoker (formely smokers)	5 (11)	10 (19)	2	2
History of skin metal allergy	0	6	14	3
Atopye	11	4	12	3

^a Uncoated = primary knee arthroplasty with e.motion.

^b Coated = primary knee arthroplasty with multilayer coated, i.e., AS e.motion.

^c Gonarthrosis patients, prior to knee arthroplasty (at present no metal implant)

^d Healthy patients without metal implant.

^e Atopy = history of hay fever and/or allergic asthma and/or atopic dermatitis.