Fate of patients with slipped capital femoral epiphysis (SCFE) in later life: risk of obesity, hypothyroidism, and death in 2,564 patients with SCFE compared with 25,638 controls

Figures & data

Figure 1. Age at onset of SCFE diagnosis with a peak between 10 and 15 years of age.

Table 1. Prevalence of obesity, hypothyroidism, depression, or death in patients with SCFE and in controls. Values are number (%)

	Control	SCFE
Comorbidities	n = 25,638	n = 2,564
Obesity	129 (0.5)	109 (4.3)
Hypothyroidism	166 (0.7)	46 (1.8)
Depression	998 (3.9)	101 (3.9)
Death	329 (1.3)	52 (2.0)

Table 3. Causes of death in patients with SCFE and in controls. Values are number (%)

	Control	SCFE
Cause of death	n = 25,638	n = 2,564
Vascular	38 (0.2)	14 (0.6)
Endocrine	5 (0.02)	5 (0.2)
Injury	70 (0.3)	8 (0.3)
Neuropsychiatric	15 (0.1)	3 (0.1)
Cancer	66 (0.3)	4 (0.2)
Suicide	36 (0.1)	4 (0.2)

Table 2. Hazard risks (HR) with 95% confidence intervals (CI) of comorbidities and all-cause mortality in patients with SCFE and in controls

Comorbidities	HR (CI)	aHR (CI) ^a
Obesity	8.7 (6.7–11.2)	8.7 (6.7–11.2)
Hypothyroidism	2.8 (2.0–3.9)	2.8 (2.0–3.9)
Depression	1.0 (0.8–1.3)	1.0 (0.8–1.3)
Death	1.6 (1.2–2.1)	1.6 (1.2–2.1)

^a Adjustment for birth year and sex.

Figure 2. Incidence density of SCFE diagnoses per 100,000 children aged 5 to 16 years in Sweden from 1977 to 2011.

Figure 3. Age at onset of obesity, hypothyroidism, depression, or death of SCFE patients. Age at onset of the diagnosis of obesity and hypothyroidism is younger in patients with SCFE than in the control group (obesity: p-value < 0.05; hypothyroidism: p-value < 0.001). No differences were found for age at diagnosis of depression or death between the two groups. The boxes represent the interquartile range and the red line median. The whisker represents the age range at diagnosis or death.The dot represents an outlier.