Figures & data
Figure 1. Morphological characterisation of DTX@ZIF-8 and DTX@ZIF-8/HA. TEM images DTX@ZIF-8 and DTX@ZIF-8/HA. Scale bar 20 nm.
![Figure 1. Morphological characterisation of DTX@ZIF-8 and DTX@ZIF-8/HA. TEM images DTX@ZIF-8 and DTX@ZIF-8/HA. Scale bar 20 nm.](/cms/asset/cc1d3068-f9b6-40d9-b5ca-8dbeec66678a/tjen_a_2307061_f0001_b.jpg)
Figure 2. A) XRD patterns of the simulated ZIF-8, pure HA, as-fabricated ZIF-8, DTX@ZIF-8, and DTX@ZIF-8/HA. B) FT-IR spectra of as-prepared ZIF-8, DTX, DTX@ZIF-8, HA, and DTX@ZIF-8/HA.
![Figure 2. A) XRD patterns of the simulated ZIF-8, pure HA, as-fabricated ZIF-8, DTX@ZIF-8, and DTX@ZIF-8/HA. B) FT-IR spectra of as-prepared ZIF-8, DTX, DTX@ZIF-8, HA, and DTX@ZIF-8/HA.](/cms/asset/9efd5e01-4cf9-437a-941b-5337d21c2339/tjen_a_2307061_f0002_c.jpg)
Figure 3. Size distributions measured by DLS of DTX@ZIF-8 and DTX@ZIF-8/HA. DTX@ZIF-8 and DTX@ZIF-8/HA dispersed in pH 7.4 PBS within 12 h and the varies of hydrodynamic diameters of DTX@ZIF-8/HA within 7 days.
![Figure 3. Size distributions measured by DLS of DTX@ZIF-8 and DTX@ZIF-8/HA. DTX@ZIF-8 and DTX@ZIF-8/HA dispersed in pH 7.4 PBS within 12 h and the varies of hydrodynamic diameters of DTX@ZIF-8/HA within 7 days.](/cms/asset/bbec6ea1-d3d7-42f5-827e-1afdfd9ec011/tjen_a_2307061_f0003_c.jpg)
Figure 4. A) UV–vis absorption spectra of ZIF-8, DTX, DTX@ZIF-8 and DTX@ZIF-8/HA. B) N2 absorption-desorption isotherms of ZIF-8 and DTX@ZIF-8. C) A) ZIF-8/HA, DTX, DTX@ZIF-8, and DTX@ZIF-8/HA were dispersed in PBS (pH = 7.4) at different concentrations and did not affect the MTT reading.
![Figure 4. A) UV–vis absorption spectra of ZIF-8, DTX, DTX@ZIF-8 and DTX@ZIF-8/HA. B) N2 absorption-desorption isotherms of ZIF-8 and DTX@ZIF-8. C) A) ZIF-8/HA, DTX, DTX@ZIF-8, and DTX@ZIF-8/HA were dispersed in PBS (pH = 7.4) at different concentrations and did not affect the MTT reading.](/cms/asset/1574a6eb-2a2c-4cbd-85ba-1201c3c15b31/tjen_a_2307061_f0004_c.jpg)
Figure 5. A) The standard curve for DTX solutions was identified at 282 nm by UV–vis. B) Difference in the loading efficacy of DTX@ZIF-8 versus concentrations of DTX. C) The absorbance spectral analysis of the initial DTX solution and the supernatant achieved after the DTX@ZIF-8. D) DTX release profiles from DTX@ZIF-8 in PBS at pH = 5.0 and 7.4.
![Figure 5. A) The standard curve for DTX solutions was identified at 282 nm by UV–vis. B) Difference in the loading efficacy of DTX@ZIF-8 versus concentrations of DTX. C) The absorbance spectral analysis of the initial DTX solution and the supernatant achieved after the DTX@ZIF-8. D) DTX release profiles from DTX@ZIF-8 in PBS at pH = 5.0 and 7.4.](/cms/asset/48af1074-4018-430f-8d41-0b2a4f89fe99/tjen_a_2307061_f0005_c.jpg)
Figure 6. A) In vitro cytotoxicity of K562 cells incubated with samples at different concentrations (0–120 μg/mL of ZIF-8 or 0–90.6 μg/mL of DTX) for 24 h. B) Cell viabilities of HUVECs with incubation of DTX@ZIF-8/HA for 24 h. C) ZIF-8/HA, DTX, DTX@ZIF-8, and DTX@ZIF-8/HA were dispersed in PBS (pH = 7.4) at different concentrations and did not affect the MTT reading.
![Figure 6. A) In vitro cytotoxicity of K562 cells incubated with samples at different concentrations (0–120 μg/mL of ZIF-8 or 0–90.6 μg/mL of DTX) for 24 h. B) Cell viabilities of HUVECs with incubation of DTX@ZIF-8/HA for 24 h. C) ZIF-8/HA, DTX, DTX@ZIF-8, and DTX@ZIF-8/HA were dispersed in PBS (pH = 7.4) at different concentrations and did not affect the MTT reading.](/cms/asset/3ca37ebf-a4d8-4de4-9f91-62c65ab51132/tjen_a_2307061_f0006_c.jpg)
Figure 7. Dual acridine orange/ethidium bromide (AO/EB) staining shows the induction of apoptosis in the K562 cells after being treated with the IC50 concentration of DTX, ZIF-8/HA, DTX@ZIF-8 and DTX@ZIF-8/HA. Scale bar 100 µm.
![Figure 7. Dual acridine orange/ethidium bromide (AO/EB) staining shows the induction of apoptosis in the K562 cells after being treated with the IC50 concentration of DTX, ZIF-8/HA, DTX@ZIF-8 and DTX@ZIF-8/HA. Scale bar 100 µm.](/cms/asset/4ba8742c-fd21-4299-99d5-6846bc5939c9/tjen_a_2307061_f0007_c.jpg)
Data availability
All data generated or analysed during this research are included in this published article.