Figures & data
Figure 1. A simplified depiction of the ITP pathogenesis along with the sites of intervention for new therapeutics (from Provan and Semple [Citation1]).
![Figure 1. A simplified depiction of the ITP pathogenesis along with the sites of intervention for new therapeutics (from Provan and Semple [Citation1]).](/cms/asset/85732b9f-7680-46d8-8988-2bcc4ee651f3/ierr_a_2318345_f0001_oc.jpg)
Table 1. Pro-thrombotic factors in ITP.
Figure 2. (a) the incidence of ITP in France (2009–2011). white bars = females diagnosed with ITP; black bars = males diagnosed with ITP. Asterisks denote statistically significant differences between the sexes (from moulis et al. [Citation56]). (b) The percentage of ITP cases which were secondary to other conditions with age in France (2009-2011). (From Moulis et al. [Citation56]). (c) Gastrointestinal and central nervous system bleeds in ITP patients by age. White bars = gastrointestinal bleeds; black bars = central nervous system bleeds. There was a statistically significant correlation between gastrointestinal bleed bleeds and age (p = 0.003) and central nervous system bleeds and age (p = 0.02). (From Moulis et al. [Citation56]).
![Figure 2. (a) the incidence of ITP in France (2009–2011). white bars = females diagnosed with ITP; black bars = males diagnosed with ITP. Asterisks denote statistically significant differences between the sexes (from moulis et al. [Citation56]). (b) The percentage of ITP cases which were secondary to other conditions with age in France (2009-2011). (From Moulis et al. [Citation56]). (c) Gastrointestinal and central nervous system bleeds in ITP patients by age. White bars = gastrointestinal bleeds; black bars = central nervous system bleeds. There was a statistically significant correlation between gastrointestinal bleed bleeds and age (p = 0.003) and central nervous system bleeds and age (p = 0.02). (From Moulis et al. [Citation56]).](/cms/asset/713a7490-cf3d-406d-a657-9d5c95a4a8de/ierr_a_2318345_f0002_b.gif)
Figure 3. An algorithm for selection of second-line treatment for ITP.
Figure 4. Fostamatinib mechanism of action. inhibition of spleen tyrosine kinase (SYK) by fostamatinib plays a key role in antibody-mediated phagocytosis of platelets.
Figure 5. Pro-inflammatory and pro-coagulation pathways affected by spleen tyrosine kinase (SYK). Fcγ = fragment, crystallizable region; IgG = immunoglobulin G; P = phosphoryl group (from Cooper et al. [Citation8]).
![Figure 5. Pro-inflammatory and pro-coagulation pathways affected by spleen tyrosine kinase (SYK). Fcγ = fragment, crystallizable region; IgG = immunoglobulin G; P = phosphoryl group (from Cooper et al. [Citation8]).](/cms/asset/fc78cd02-34a3-46fc-a5c3-b46b3b37f823/ierr_a_2318345_f0005_oc.jpg)