454
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Early diagnosis of persons with von Willebrand disease using a machine learning algorithm and real-world data

, , , , &
Pages 261-268 | Received 22 Dec 2023, Accepted 07 May 2024, Published online: 24 May 2024

Figures & data

Figure 1. Key project phases of the machine learning approach to identify potentially undiagnosed symptomatic patients with VWD. HCP, healthcare professional; VWD, von Willebrand disease.

Figure 1. Key project phases of the machine learning approach to identify potentially undiagnosed symptomatic patients with VWD. HCP, healthcare professional; VWD, von Willebrand disease.

Table 1. Main predictors used to develop the prediction model.

Table 2. Selection criteria.

Table 3. Models and cutoff probability applied in male and female patients of undiagnosed cohort.

Figure 2. Age distribution.

Figure 2. Age distribution.

Figure 3. Key characteristics of symptomatic patients suspected to have undiagnosed VWD. aRespiratory bleeding includes: epistaxis, hemorrhage from throat, hemorrhage from respiratory passages, unspecified, hemorrhage from other sites in respiratory passages, hemoptysis. bBlood chemistry panel tests include: collection of venous blood by venipuncture, blood count, comprehensive metabolic panel, lipid panel, basic metabolic panel, ferritin, hemoglobin glycosylated (A1c), iron, iron binding capacity; hemoglobin. cThe products used to treat bleeding are not mutually exclusive; patients may have received combinations of treatments. DDAVP, 1-deamino-8-D-arginine vasopressin; ER, emergency room; FVIII:C, factor VIII coagulant activity; IUD, intrauterine device; PTT, partial thromboplastin time; VWD, von Willebrand disease; VWF, von Willebrand factor; VWF:Ag, von Willebrand factor antigen; VWF:RCo, VWF ristocetin cofactor.

Figure 3. Key characteristics of symptomatic patients suspected to have undiagnosed VWD. aRespiratory bleeding includes: epistaxis, hemorrhage from throat, hemorrhage from respiratory passages, unspecified, hemorrhage from other sites in respiratory passages, hemoptysis. bBlood chemistry panel tests include: collection of venous blood by venipuncture, blood count, comprehensive metabolic panel, lipid panel, basic metabolic panel, ferritin, hemoglobin glycosylated (A1c), iron, iron binding capacity; hemoglobin. cThe products used to treat bleeding are not mutually exclusive; patients may have received combinations of treatments. DDAVP, 1-deamino-8-D-arginine vasopressin; ER, emergency room; FVIII:C, factor VIII coagulant activity; IUD, intrauterine device; PTT, partial thromboplastin time; VWD, von Willebrand disease; VWF, von Willebrand factor; VWF:Ag, von Willebrand factor antigen; VWF:RCo, VWF ristocetin cofactor.
Supplemental material

Supplemental Material

Download MS Word (55 KB)