ABSTRACT
Objective
To date, some studies revealed that HHIP gene polymorphisms may be associated with the risk of chronic obstructive pulmonary disease (COPD). Therefore, this meta-analysis explored the association between single-nucleotide polymorphisms (SNPs) of the human hedgehog interacting protein (HHIP) gene and susceptibility to COPD.
Methods
Seven Chinese and English electronic databases were searched for eligible studies up to 30 May 2020. After the inclusion criteria were strictly followed, the Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included studies. The pooled odds ratio (OR) of the 95% confidence interval (CI) under four different genetic models was calculated to evaluate the association strength between the SNPs and COPD. Egger’s test was used to evaluate publication bias.
Results
This meta-analysis was registered at PROSPERO (CRD42021235708). In total, 12 studies involving 6623 COPD patients and 11,373 healthy controls were included. Regarding rs13118928 and rs1828591, an A > G mutation increased the risk of COPD in Asian and Caucasian individuals, and the rs13147758 A > G mutation and rs10519717 C > T mutation increased the risk of COPD only in Asian people. No significant publication bias was observed.
Conclusion
This meta-analysis provides a theoretical basis suggesting that HHIP gene polymorphisms may be associated with the risk of COPD.
Acknowledgments
We would like to thank American Journal Experts for their assistance with language editing.
Contributions statement
Yi Liao and Yue Liao conceived of and designed the study, acquired and analyzed the data and wrote the manuscript. Fuqiang Wen contributed to the data analysis and manuscript preparation. All authors read and approved the manuscript and agree to be accountable for all aspects of the research in ensuring that the accuracy or integrity of any part of the work is appropriately investigated and resolved.
Declaration of Interests
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Data availability statement
All data generated or analyzed in this study are included in this published article.
Ethical approval
All analyses in the current study were consistent with established medical ethics guidelines.
Informed consent
The current study is based on a publicly available dataset. Thus, informed consent was not needed.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Supplemental data
Supplemental data for this article can be accessed https://doi.org/10.1080/17476348.2022.2030226