A cloud-based platform for the non-invasive management of coronary artery disease

ABSTRACT

We present the architecture and the usability testing of a novel cloud-based platform, which integrates cyber-physical systems and interoperability standards enabling a clinical decision support system for risk stratification, diagnosis, prognosis and treatment of CAD. In this work multi-disciplinary human data were used for the development of machine learning and computational biomechanics based predictive models. Two Lab-on-Chip devices have been integrated into the cloud platform. A targeted RNA-panel provides the mRNA gene expression values for the stratification algorithm. The results of the usability testing demonstrate that the platform is efficient, accurate and performs all developed tasks quickly.

KEYWORDS:

• Cardiovascular disease
• cloud-platform
• CDSS
• cyber-physical systems
• interoperability

Acknowledgments

This study was supported by the European Union Horizon 2020 research and innovation programme under grant agreement No 689068 - Project “Simulation Modeling of coronary ARTery disease: a tool for clinical decision support (SMARTool)”. This publication reflects only the authors' view and the Commission is not responsible for any use that may be made of the information it contains.

Disclosure statement

Joao Correia and Francisco sans are working for Biotronics3D.

Paolo Stofella and Valiani Massimiliano are working for EXPRIVIA SpA.

Notes

1. 3Dnet (www.3dnetmedical.com) is a domestic cloud platform providing IHE compliant integration and modular SaaS solutions that include managed services, visualisation and interoperability. 3Dnet delivers the functionality of VNA, RIS and Diagnostic Visualisation as distinct subscription packages from the UK-based ISO27001 accredited datacentre – providing security, redundancy, reliability and scalability through onshore outsourcing. The zero-footprint client delivers images in full diagnostic quality with advanced functionality like MPR, CPR and volume rendering from any internet browser on any operating system. Our mobile portal provides referential image and document viewing on mobile devices. The 3Dnet Gateway, a proprietary software node, can be configured with multiple DICOM & HL7 systems. Regardless of vendor or physical.

2. Regulation (EU) 2016/679 of the European Parliament.

3. http://www.bioirc.ac.rs/index.php/software.

Additional information

Funding

This work is partially funded by the European Commission: Project SMARTOOL, ‘Simulation Modeling of coronary ARTery disease: a tool for clinical decision support — SMARTool’ (GA number: 689068).