Three component one-pot synthesis of novel pyrimidino thiazolidin-4-ones catalyzed by activated fly ash

Figures & data

Figure 1.  Flow chart for the preparation of activated fly ash.

short-legendScheme 1. Multicomponent reaction for the synthesis of novel 2-phenyl-3-(4,6-diarylpyrimidin-2-yl) thiazolidin-4-ones in “dry media” under microwave irradiation.

Table 1. Physical and analytical data of 2-phenyl-3-(4,6-diarylpyrimidin-2-yl) thiazolidin-4-ones 12–22.

							Elemental analysis (%)
Entry	X	Z	Y	Yield (%)	Reaction time (s)	m.p°C	C Found (calculated)	H Found (calculated)	N Found (calculated)	m/z (M + 1)^+• Molecular formula
12	H	H	H	92 (65)	180 (620)	145	73.31	4.60	10.23	410
							(73.35)	(4.64)	(10.26)	C25H19N3OS
13	H	H	Cl	90 (52)	240 (900)	162	67.65	4.04	9.41	444
							(67.66)	(4.06)	(9.46)	C25H18Cl N3OS
14	H	Cl	H	85 (49)	300 (720)	130	67.62	4.01	9.44	444
							(67.66)	(4.06)	(9.46)	C25H18Cl N3OS
15	H	H	OCH3	95 (60)	120 (600)	110	71.03	4.72	9.51	440
							(71.08)	(4.78)	(9.56)	C26H21N3O2S
16	H	H	CH3	90 (65)	180 (600)	162	73.72	4.92	9.89	424
							(73.76)	(4.96)	(9.92)	C26H21N3OS
17	H	H	F	85 (70)	240 (720)	104	70.23	4.18	9.79	428
							(70.27)	(4.21)	(9.83)	C25H18FN3OS
18	Cl	H	H	85 (65)	300 (900)	114	67.64	4.01	9.41	444
							(67.66)	(4.05)	(9.46)	C25H18Cl N3OS
19	OCH3	H	H	90 (58)	240 (780)	137	71.02	4.72	9.55	440
							(71.08)	(4.78)	(9.56)	C26H21N3O2S
20	Cl	H	CH3	85 (55)	300 (600)	125	68.17	4.32	9.15	458
							(68.21)	(4.36)	(9.17)	C26H20ClN3OS
21	Cl	H	Cl	88 (60)	240 (600)	130	62.71	3.52	8.76	479
							(62.78)	(3.55)	(8.78)	C25H17Cl2N3OS
22	Cl	H	F	90 (65)	240 (660)	103	64.98	3.65	9.04	462
							(65.02)	(3.68)	(9.09)	C25H17ClFN3OS
Note: The values in parentheses are the reaction conditions in classical method.

short-legendScheme 2. Proposed mechanism for the formation of pyrimidino thiazolidin-4-ones.