Green technologies in organic synthesis: self-condensation of enamines, enaminones and enaminoesters under microwave irradiation in ionic liquid

Figures & data

short-legendScheme 1. Synthesis of 1,3,5-trisubstituted benzene 3a,b.

short-legendScheme 2. Synthesis of 1,3,5-triaroyl benzene 7a-j.

Table 1. Comparing yield of 7a–j using thermal and microwave irradiation in the presence of IL.

		Yield		Time (min)
Compound number	R	Δ	µw	Δ	µw	Literature yield
7a	phenyl	86	91	20	1	79^(12)
7b	2-thienyl	88	97	20	1	85^(12)
7c	C6H4Cl-p	100	100	20	1	–
7d	C6H4Me-p	99	100	20	1	–
7e	2-pyrrolyl	70	100	20	1	–
7f	2-pyridyl	72	100	20	1	89^(12)
7g	C6H4Br-p	94	95	20	1	–
7h	methyl	60	70	20	1	65^(12)
7i	2-furyl	64	87	20	1	87^(12)
7j	C6H4NO2-p	100	100	20	1	–

Figure 1.  Molecular structure of 9 with atoms labeling scheme.

short-legendScheme 3. Synthesis of 2,2′,2′′-(2,2′,2′′-(Benzene-1,3,5-triyl)tris(2-oxoethane-2,1-diyl))triisoindoline-1,3-dione 9.

short-legendScheme 4. Synthesis of triethyl benzene-1,3,5-tricarboxylate 14.

short-legendScheme 5. Synthesis of 2-aryl-5-aroylpyridines 17a-e.