Green route synthesis of 4-thiazolidinone analogs of isonicotinic acid hydrazide

Figures & data

short-legendScheme 1. Synthesis of intermediate Schiff's bases by sonication.

short-legendScheme 2. Synthesis of 4-thiazolidinone analogs using Schiff's bases by stirring.

short-legendScheme 3. Synthesis of 4-thiazolidinone analogs using Schiff's bases by sonication.

Table 1. Chemical structures and properties of Schiff's bases of isoniazid by sonication (2a–2e).

Note: Ethanol was employed for recrystallisation.

^aAll melting points are uncorrected.

^bExpressed in cm^−1; KBr.

Table 2. Chemical structures and properties of 4-thiazolidinones (3a–3e).

Note: Ethanol was employed for recrystallisation.

^a All melting points were uncorrected.

^b Expressed in cm^-1; KBr.

Table 3. Isonicotinoyl hydrazones and their 4-thiazolidinone analogs.