Hydrotrope induced synthesis of 1,8-dioxo-octahydroxanthenes in aqueous medium

Figures & data

Scheme 1.  Hydrotrope induced synthesis of 1,8-dioxo-octahydroxanthenes.

Table 1. Screening of various hydrotropes for synthesis of 1,8-dioxo-octahydroxanthenes.^a

Hydrotrope	Time (min)	Yield^b (%)
p-Toluene sulphonate (NaPTSA)	60	87
p-Xylene sulphonate (NaXS)	90	72
Benzene sulphonate (NaBS)	120	63
^aAll products were characterized by ^1H, ^13C NMR, and IR spectroscopy.
^bIsolated yields after recrystallization.

Table 2. Synthesis of 1,8-dioxo-octahydroxanthene in 50% aq. NaPTSA solution.

Figure 1.  Recyclability performance of 50% aq. NaPTSA in 1,8-dioxo-octahydroxanthene synthesis.