Solvent-free microwave-assisted synthesis of E-(1)-(6-benzoyl-3,5-dimethylfuro[3′,2′:4,5]benzo[b]furan-2-yl)-3-(aryl)-2-propen-1-ones and their antibacterial activity

Figures & data

Table 1. Physical and analytical data for E-(1)-(6-benzoyl-3,5-dimethylfuro[3′,2′:4,5]benzo[b]furan-2-yl)-3-(aryl)-2-propen-1-ones.

		Conventional method		Microwave method
Compound no.	M.P. (°C)	Time (h)	Yield (%)	Time (min)	Yield (%)
3a	242—244	6	68	5	92
3b	220—223	7	64	5	90
3c	270—271	7	65	4	94
3d	272—274	6	64	4	89
3e	246—248	8	66	5	92
3f	275—276	8	56	5	87
3g	255—257	8	53	5	93

short-legendScheme 1. Synthesis of E-(1)-(6-benzoyl-3,5-dimethylfuro[3′,2′:4,5]benzo[b]furan-2-yl)-3-(aryl)-2-propen-1-ones (3a–g).

Table 2. Antibacterial activity of compounds 3a–g and inhibition zones.

	Gram–positive bacteria		Gram-negative bacteria
Compound no.	Bacillus subtilis (ATCC-6633) (mm)	Staphylococcus aureus (ATCC-29737) (mm)	Escherichia coli (ATCC-10536) (mm)	Pseudomonas aeruginosa (ATCC-27853) (mm)
3a	15	10	9	10
3b	16	9	10	9
3c	10	8	7	7
3d	10	8	8	6
3e	9	7	7	8
3f	16	10	10	9
3g	17	10	11	10
Standard	22 (streptomycin)	15 (tetracycline)	13 (chloramphenicol)	13 (carbenicillin)