PEG-600-mediated, green and efficient, tandem syntheses of N-subtituted-2-styrylquinazolin-4- ones

Figures & data

short-legendScheme 1. Synthesis of N-substituted 2-styrylquinazolinones.

Table 1. Synthesis of N-substituted-2-styrylquinazolinones (5a–l).

			Routes
			STEP WISE -I		STEP WISE -II		TANDEM-I		TANDEM-II
			1235		1235		1 2 3 5		1 2 4 5
			Total	Over all	Total	Over all	Total	Over all	Total	Over all
Product	R	–Ar	Time (hr)	Yield (%)	Time (hr)	Yield (%)	Time (hr)	Yield (%)	Time (hr)	Yield (%)
5a	–CH3	–C6H5	5	59	5	64	4.5	90	4.5	90
5b	–CH3	–C6H4(4-OCH3)	5	63	5	65	4.5	91	4.5	89
5c	–CH3	–C6H3 (3-OC2H5) (4-OCH3)	5	61	5	65	4.5	90	4.5	91
5d	–CH3	–C6H4(2-OH)	5	61	5	64	4.5	92	4.5	93
5e	–C2H5	–C6H5	4.5	58	4.5	60	4	90	4	93
5f	–C2H5	–C6H4(4-OCH3)	4.5	61	4.5	62	4	92	4	92
5g	–C2H5	–C6H3 (3-OC2H5) (4-OCH3)	4.5	55	4.5	60	4	90	4	92
5h	–C2H5	–C6H4(2-OH)	4.5	60	4.5	62	4	90	4	92
5i	–C-CH2-C6H5	–C6H5	4.5	61	4.5	59	4	90	4	93
5j	–CH2-C6H5	–C6H4(4-OCH3)	4.5	60	4.5	58	4	92	4	92
5k	–CH2-C6H5	–C6H3 (3-OC2H5) (4-OCH3)	4.5	58	4.5	60	4	90	4	92
5l	–CH2-C6H5	–C6H4(2-OH)	4.5	56	4.5	57	4	89	4	92

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