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Figures & data
Figure 1. Chemical structure of some pharmaceutically important compounds prepared by the Strecker reaction.
Scheme 1. (A) The Strecker reaction of different aldehydes and amines with TMSCN; and (B) synthesis of imines catalyzed by pure MCM-41 (1a).
Scheme 2. Proposed mechanism for the Strecker reaction of aldehydes 2 and amines 3 with TMSCN or the formation of imines (5) catalyzed by pure MCM-41 (1a).
Table 1. Three-component Strecker reaction of 4-chlorobenzaldehyde (2a) and aniline (3a) with TMSCN under solvent-free conditions.a
Table 2. Three-component Strecker reaction of various aldehydes 2 and amines 3 with TMSCN catalyzed by pure MCM-41 (1a) under optimal conditions.a
Figure 2. Recyclability of MCM-41 catalyst (1a) for four consecutive runs of the model reaction.
Table 3. Comparison of the catalytic efficiency of MCM-41 with other heterogeneous catalysts for the synthesis of α-aminonitrile 4g.
Table 4. Preparation of different imines 5 by the reaction of aldehydes 2 and amines 3 catalysed by MCM-41 (1a).a
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