Figures & data
Scheme 1. Synthesis of hydrazono-thiazolone derivative 6a.
Scheme 2. Different synthetic pathways of hydrazono-thiazolone derivative 6a.
Table 1. A comparative yield percentage of compound 6a via different synthetic pathways.
Scheme 3. Synthesis of 2-hydrazonothiazolidin-4(5H)-one with different heterocycles moieties.
Table 2. Percentage yields of 2-hydrazonothiazolidin-4(5H)-ones (6a-m).
Table 3. Preliminary antibacterial activity for compounds 6a-l (10 mM).
Figure 1. Antibacterial activity of compounds 6a-l based on MICs values.
Table 4. MICs of the synthesized compounds against the tested pathogenic bacteria.Table Footnotea
Figure 2. 2D Binding of ciprofloxacin with 4DUH.
Table 5. Docking score (kcal/mol), No. of H-bonding, No. of arene interaction, and RMSD of most potent synthesized compounds with 4DUH receptor when compared to Ciprofloxacin.
Figure 4. Bioavailability radar of the most potent compounds versus Ciprofloxacin.
Table 6. The physicochemical properties, lipophilicity, pharmacokinetic characteristics, and drug likeness matching of the most potent thiazolidinone derivatives.