Prevalence of non-infectious comorbidities in the HIV-positive population in Belgium: a multicenter, retrospective study

Figures & data

Table 1. Patient characteristics in four AIDS reference centers (ARCs) in Belgium, 2014–2016.

	n (%)	SD
Follow-up	5787
Mean age	46.7	11.6
Male gender	3609 (62.4%)
On treatment^a	4648 (95.3%)
Region of origin
Europe	2726 (47.1%)
Sub-Saharan Africa	2452 (42.4%)
Latin America/Caribbean	179 (3.1%)
Asia	146 (2.5%)
Other	284 (4.9%)
CD4 count
Mean recent CD4 (cells/mm^3)	566.2	280.1
<200	454 (8.3%)
200–349	772 (14.1%)
350–499	1173 (21.4%)
500+	3126 (57.1%)
Mean nadir CD4 (cells/mm^3)^b	268.8	189.5
<200	1740 (39.0%)
200–349	1528 (34.3%)
350–499	722 (16.2%)
500+	470 (10.5%)
Other risk factors
Smoking (former or current)^c	1849 (39.9%)
Hepatitis C RNA positive	164 (2.8%)

^a Only includes patients with known treatment status (n = 4880, 84.3% of sample).

^b Only includes patients with known nadir CD4 (n = 4880, 84.3% of sample).

^c Only includes patients with known smoking status (n = 4636, 80.1% of sample).

Table 2. Prevalence of non-infectious comorbidities (NICMs) in four AIDS reference centers (ARCs) in Belgium, 2014–2016.

NICM	All ages (n = 5787) (%)	≤40 years (n = 1833) (%)	41–50 years (n = 1824) (%)	51–60 years (n = 1433) (%)	>60 years (n = 695) (%)
Diabetes mellitus	5.9	1.8	4.5	10.1	12.2
Arterial hypertension	31.0	16.5	30.2	43.7	45.2
Cardiovascular events^a	2.9	0.6	1.3	5.1	8.0
Chronic kidney disease	7.8	1.8	5.2	10.6	24.8
Anal cancer	0.3	0.2	0.2	0.7	0.4
Hodgkin’s lymphoma	0.5	0.2	0.4	0.9	0.6
Lung cancer	0.1	0	0.1	0.3	0
Liver cancer	0.1	0	0	0.1	0.1
Polypathology	8.9	2.1	5.3	14.6	24.5

^a Only includes patients for whom data on CE was available (n = 4880, 84% of sample).

Table 3. Differences in mortality among patients with or without DM, CE, CKD, HCV, or polypathology 2014–2016.

NICM or risk factor	Prevalence – living patients (n = 5787) (%)	Prevalence – deceased patients (n = 31) (%)	OR	95% CI	p value
Diabetes mellitus	5.9	12.9	2.3	0.6–6.8	0.1110
Arterial hypertension	31.0	16.1	0.4	0.1–1.1	0.0811
Cardiovascular events^a	2.9	8.0	2.9	0.3–11.9	0.1660
Chronic kidney disease	7.7	22.6	3.5	1.3–8.4	0.0085**
Hepatitis C virus	2.8	16.1	6.6	2.0–17.7	0.0018**
Polypathology	8.9	19.4	2.5	0.8–6.2	0.0541

^a Only includes patients for whom data on CE was available (n = 4880, 84% of sample).

**indicates significance at the p < 0.05 level.