Non-primary CMV infection not always innocent. A case-report and literature review

ABSTRACT

Objectives

Cytomegalovirus (CMV) is the most common infectious cause of congenital malformations. CMV infections are frequently symptomatic in case of a primary infection during pregnancy. Generally, maternal immunity protects the newborn against a symptomatic course of the CMV infection.

Methods

We present clinical information and medical images of a neonate with non-primary congenital CMV infection.

Results

We report the case of a severe congenital infection in a newborn clinically presenting with diffuse petechia, facial dysmorphisms, respiratory distress, hepatomegaly and hypotonia. The girl was born to a mother with CMV immunity. Blood results demonstrated thrombocytopenia and elevated transaminases. Brain MRI revealed ventricular dilatation and germinolytic cysts, compatible with CMV infection. Auditory brain stem response testing was abnormal. CMV culture of saliva was positive. This led to the diagnosis of a severe congenital CMV infection due to a non-primary maternal infection. Antiviral treatment with valganciclovir was initiated immediately and continued for 6 months.

Conclusion

Our case illustrates that, even when the mother was demonstrated CMV immune, congenital CMV infection is still an important differential diagnostic consideration in neonates presenting with congenital cerebral abnormalities, thrombocytopenia and/or hearing loss.

Abbreviations

ABR: auditory brainstem responses; CMV: Cytomegalovirus; CPAP: Continuous Positive Airway Pressure; CRP: C-Reactive Protein; dBnHL: Decibel Above Normal Adult Hearing Level; IV: intravenously; MRI: Magnetic Resonance Imaging; SGA: Small for Gestational Age; SNHL: Sensorineural Hearing Loss

KEYWORDS:

• Cytomegalovirus
• neonate
• immunity
• congenital infection
• diagnosis

Disclosure statement

The authors have not disclosed any potential conflicts of interest or financial support from any pharmaceutical company.

Geolocation information

Division of Neonatology, University Antwerp Hospital, 10, Wilrijkstraat, BE-2650 Edegem, Belgium.

Additional information

Funding

This work was not supported by any funding agency.