Interaction between the melanocortin 1 receptor (MC1R) and agouti signalling protein genes (ASIP), and their association with black and brown coat colour phenotypes in peruvian alpaca

Figures & data

Table 1. ASIP and MC1R alleles in Peruvian alpacas.

	ASIP
Allele	g3836C > T pR98C	g3866-3923del57 C109_R127del	g3896G > A pR118H
A	C	–	G
a^H	C	–	A
a^ht	T	–	G
a^Δ57	C	Yes
Allele	MC1R
	g82A > G pT28A	g259A > G pV87M	g376A > G pG126S	g901C > T pR301C
E	A	A	A	C
e	G	G	G	T

ASIP: agouti signalling protein; MC1R: melanocortin 1 receptor.

Table 2. Alpaca ASIP-MC1R genotype combinations in the two coat colours.

Colour	ASIP	MC1R
	a^H/a^Δ57
Black		E/E
	a^H/a^ht
	a^H/a^Δ57
Black		E/e
	a^H/a^ht
	A/a^ht
Brown		E/e
	A/A

ASIP: agouti signalling protein; MC1R: melanocortin 1 receptor.

Table 3. Crosses involving 5 full black sires and 10 dams.

Black ram genotype	Black dam genotype	Black offspring genotype
a^H/a^hT – EE	a^H/a^hT – E/e	a^H/a^hT – E/E
	a^H/a^hT – E/E	a^H/a^hT – E/E
a^H/a^Δ57– EE	a^H/a^Δ57– E/E	a^H/a^Δ57– E/E
	a^H/a^Δ57– E/e	a^H/a^Δ57 – E/E
a^H/a^hT – EE	a^H/a^Δ57– E/E	a^H/a^Δ57– E/E
	a^H/a^Δ57– E/e	a^H/a^Δ57– E/E
a^H/a^hT – E/e	a^H/a^Δ57– E/E	a^H/a^Δ57– E/E
a^H/a^Δ57– EE	a^H/a^Δ57– E/e	a^H/a^Δ57– E/E
	a^H/a^Δ57– E/e	a^H/a^Δ57– E/E
	a^H/a^Δ57– E/e	a^H/a^Δ57– E/E