Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer?

Figures & data

TABLE 1. Comparison of studies on iatrogenic Creutzfeldt-Jakob disease (iCJD) and Aβ deposition. AD: Alzheimer disease; GH: growth hormone; NA: not addressed in the study; Nr: number. * Indicates that these cases were included in Study 2 also.

Study	Study 1	Study 2	Study 3	Study 4
Type of iCJD	Pituitary-derived GH	Dura mater	Dura mater	Dura mater
Number of iCJD cases examined	8	7	2*	16
Nr. of iCJD with parenchymal Aβ deposits	4 + 2 focal	5	2*	13
Distinct morphology or distribution of parenchymal Aβ	NA	NA	Yes	Subpial accumulation emphasized. Morphology of parenchymal plaques not commented.
Nr. of iCJD with CAA	3 + 1 focal	5	2*	11
Cadaveric tissue examined	No	No	Yes	No
Non-cadaveric tissue examined	Yes: pituitary (55 samples)	No	Yes: dura mater (84 samples)	No
AD related tau pathology	No	No	No	Yes - details not provided
Genetic aspects	APOE + AD genes	NA	APOE + AD genes	APOE
Statistical difference when compared to sCJD	Yes	Yes	NA	Yes
Age of iCJD cases with parenchymal Aβ	4th decade to 51	28–63	28, 33	35–81
Age of iCJD cases with CAA	5th decade to 51	28–63	28, 33	35–81
Age of cases < 40 y with parenchymal Aβ deposits	36 (focal)	28, 33	28, 33	35, 39
Age of cases < 40 y with CAA	–	28, 33	28, 33	35, 39
Clinical phenotype	CJD	CJD	CJD	CJD
Reference	25	27	28	29