Figures & data
Figure 1. The diagram illustrating that in neurodegenerative diseases, instead of polarization according to the bidirectional A1-A2 or neurotoxic-neuroprotective model, reactive astrocytes adopt multiple, disease-specific states dictated in part by a nature of an insult. Within individual diseases, reactive states might vary across brain regions at any given time point of the disease (represented by dark and light grey arrows)
Figure 2. Schematic diagram illustrating that dysregulation of multiple neuroprotective and neurotoxic mechanisms might contribute to defining a net outcome of reactive astrocyte phenotype
