Figures & data
Table 1. Characteristics of included studies.
Table 2. Expression changes of ASICs in intervertebral disc.
Table 3. Functional description of ASICs in intervertebral disc degeneration.
Li X, Wu FR, Xu RS, et al. Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs. Expert Opin Ther Targets. 2014;18:1–14. Cuesta A, Del Valle ME, Garcia-Suarez O, et al. Acid-sensing ion channels in healthy and degenerated human intervertebral disc. Connect Tissue Res. 2014;55:197–204. Cai F, Wang F, Hong X, et al. Acid-sensing ion channel 1a regulates the survival of nucleus pulposus cells in the acidic environment of degenerated intervertebral discs. Iran J Basic Med Sci. 2016;19:812–820. Sadowska A, Kameda T, Krupkova O, et al. Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity. Eur Cell Mater. 2018;36:231–250. Sun X, Jin J, Zhang JG, et al. Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs. Acta Biochim Biophys Sin. 2014;46:774–781. Cuesta A, Vina E, Cabo R, et al. Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc. Int J Clin Exp Pathol. 2015;8:10305–10314. Uchiyama Y, Guttapalli A, Gajghate S, et al. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res. 2008;23:1619–1628. Zhang F, Zhao X, Shen H, et al. Molecular mechanisms of cell death in intervertebral disc degeneration (Review). Int J Mol Med. 2016;37:1439–1448. Yuan FL, Zhao MD, Jiang DL, et al. Involvement of acid-sensing ion channel 1a in matrix metabolism of endplate chondrocytes under extracellular acidic conditions through NF-kappaB transcriptional activity. Cell Stress Chaperones. 2016;21:97–104. Uchiyama Y, Cheng CC, Danielson KG, et al. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. J Bone Miner Res. 2007;22:1996–2006. Gilbert HTJ, Hodson N, Baird P, et al. Acidic pH promotes intervertebral disc degeneration: acid-sensing ion channel −3 as a potential therapeutic target. Sci Rep. 2016;6:37360. Wang D, Zhu H, Cheng W, et al. Effects of hypoxia and ASIC3 on nucleus pulposus cells: from cell behavior to molecular mechanism. Biomed Pharmacother. 2019;117:109061.