Bibliometric analysis of nicotinic acetylcholine receptors channel research (2000-2020)

Figures & data

Figure 1. Flow chart of nAChR channels researches inclusion

Figure 2. The number of annual publications on nAChR channel research from 2000 to 2020

Table 1. The top 10 countries and institutions contributed to publications on nAChR channel research

Rank	Country/Territory	Frequency	Institution	Frequency
1	USA	2905	UNIVERSITY OF CALIFORNIA SYSTEM	306
2	PEOPLES R CHINA	672	UTAH SYSTEM OF HIGHER EDUCATION	209
3	ENGLAND	418	UNIVERSITY OF UTAH	208
4	GERMANY	370	CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS	182
5	JAPAN	359	STATE UNIVERSITY SYSTEM OF FLORIDA	163
6	FRANCE	302	NATIONAL INSTITUTES OF HEALTH NIH USA	128
7	AUSTRALIA	287	US DEPARTMENT OF VETERANS AFFAIRS	127
8	ITALY	265	UNIVERSITY OF FLORIDA	123
9	CANADA	205	PENNSYLVANIA COMMONWEALTH SYSTEM OF HIGHER EDUCATION PCSHE	120
10	SWITZERLAND	161	LE RESEAU INTERNATIONAL DES INSTITUTS PASTEUR RIIP	119

Figure 3. The analysis of countries and institutions. (a). The network of countries/territories engaged in nAChR channel research; (b). The network of institutions engaged in nAChR channel research

Table 2. The top 10 journals that published articles on nAChR channel research

Rank	Journal	Frequency(%)	IF 2019	Country Affiliation
1	Journal of Biological Chemistry	212(3.659%)	4.238	United State
2	Neuropharmacology	186(3.21%)	4.431	England
3	Journal of Neuroscience	167(2.882%)	5.673	United State
4	Plos One	160(2.761%)	2.74	United State
5	Molecular Pharmacology	140(2.416%)	3.664	United State
6	Journal of Pharmacology And Experimental Therapeutics	119(2.054%)	3.561	United State
7	Journal of Neurochemistry	104(1.795%)	4.066	England
8	Journal of Medicinal Chemistry	98(1.691%)	6.205	United State
9	Proceedings of The National Academy of Sciences of The United States of America	89(1.536%)	9.412	United State
10	British Journal of Pharmacology	87(1.502%)	7.73	England

Table 3. The top 10 active authors in nAChR channel research

Rank	Author	Frequency
1	Mcintosh JM	160
2	Papke RL	82
3	Damaj MI	75
4	Lester HA	75
5	Lukas RJ	68
6	Bertrand D	59
7	Adams DJ	57
8	Gotti C	55
9	Marks MJ	54
10	Changeux JP	52

Figure 4. The network of authors contributed to nAChR channel research

Table 4. The top 10 Co-cited (CR) in nAChR channel research

Rank	Frequency	Author	Year	Source	Co-cited Reference
1	460	Unwin N	2005	Journal of Molecular Biology	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
2	286	Albuquerque EX	2009	Physiological Reviews	Mammalian nicotinic acetylcholine receptors: from structure to function
3	284	Brejc K	2001	Nature	Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
4	264	Miyazawa A	2003	Nature	Structure and gating mechanism of the acetylcholine receptor pore
5	260	Celie PHN	2004	Neuron	Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.
6	239	Bocquet N	2009	Nature	X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
7	226	Karlin A	2002	Nature Reviews. Neuroscience	Emerging structure of the nicotinic acetylcholine receptors.
8	214	Hilf RJC	2008	Nature	X-ray structure of a prokaryotic pentameric ligand-gated ion channel.
9	214	Hansen SB	2005	The EMBO Journal	Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.
10	193	Hibbs RE	2011	Nature	Principles of activation and permeation in an anion-selective Cys-loop receptor.

Figure 5. The analysis of Co-cited references: Co-citation network of references from publications on nAChR channel research

Figure 6. The 15 research areas on nAChR channel research

Table 5. Top 20 keywords in terms of frequency in nAChR channel research

Rank	keywords	Frequency	Rank	keywords	Frequency
1	nicotinic acetylcholine receptor	1758	11	brain	376
2	acetylcholine receptor	1178	12	agonist	363
3	expression	669	13	binding site	355
4	nicotine	651	14	ion channel	340
5	activation	640	15	acetylcholine	339
6	nicotinic receptor	557	16	crystal structure	332
7	subunit	524	17	mechanism	330
8	rat	493	18	protein	321
9	binding	429	19	neuron	307
10	alzheimers disease	425	20	nachr	305

Figure 7. The analysis of keywords in nAChR channel research

Table 6. Top 25 keywords with the strongest citation bursts

(The format of Table 6 is variable, and the picture format is as follows:)