Bibliometric analysis of recent research on the association between TRPV1 and inflammation

Figures & data

Figure 1. Analysis of annual publications. The numbers of annual publications on TRPV1 channel and inflammation.

Figure 2. Analysis of country and institution. (a) The publication distribution related to TRPV1 channel and inflammation of top 10 countries; (b) Network map of the main countries of publications by CiteSpace; (c) Network map of institutions in the research about TRPV1 channel and inflammation; (d) The publication distribution related to TRPV1 channel and inflammation of top 11 institutions. The purple round represents centrality. Nodes with high centrality are usually regarded as pivotal points in the field.

Table 1. Top 10 countries/regions of publications and centrality in TRPV1 channel and inflammation field.

	Publications				Centrality
Rank	Country/region	Frequency (N = 2065)	Percentage		Rank	Country/region	counts
1	USA	548	26.54%		1	Switzerland	0.69
2	Peoples R China	257	12.45%		2	Romania	0.63
3	Germany	142	6.88%		3	Finland	0.55
4	England	139	6.73%		4	Germany	0.48
5	Japan	138	6.68%		5	USA	0.44
6	Italy	101	4.89%		6	South Korea	0.36
7	Brazil	74	3.58%		7	Portugal	0.34
8	South Korea	73	3.54%		8	Austria	0.25
9	Canada	68	3.29%		9	Russia	0.24
10	Hungary	60	2.91%		10	Sweden	0.22

Table 2. Top 10 institutions of publications and centrality in TRPV1 channel and inflammation field.

	Rank	Institution	Frequency (N = 3395)	Percentage
Amounts	1	University of California, San Francisco	35	1.03%
	2	Duke University	33	0.97%
	3	University Erlangen-Nuremberg University of Kentucky	32	0.94%
	5	University of Pittsburgh	31	0.91%
	6	King’s College London	29	0.85%
	7	Seoul National University	28	0.82%
	8	University of Pecs	26	0.77%
	9	University of Florence	25	0.74%
	10	University of Szeged University of Calgary	24	0.71%
Centrality	1	University of California, San Francisco	0.18
	2	University of Florence National Cancer Institute	0.12
	4	New York University	0.11
	5	Consiglio Nazionale delle Ricerche	0.10
	6	University of California,Davis Indiana University	0.09
	8	Charite University Hospital Kaohsiung Medical University	0.08

Figure 3. The dual-map overlay of journals related to TRPV1 channel and inflammation research. Colored curves symbolized paths of references, where each curve originated from a citing journal on the left side of the dual-map and pointed at a cited journal on the right side.

Figure 4. Analysis of journals and co-cited journals in TRPV1 channel and inflammation. (a) the distribution density of journals in the research by VOSviewer; (b) Network map of co-cited journals in the research by CiteSpace; (c) Top 25 cited journals with the strongest citation bursts in the research by CiteSpace.

Table 3. Top 10 productive journals in TRPV1 channel and inflammation field.

Rank	Journal	Counts	Citations	Citations per paper	Impact factors (2021)	JCI quartile (2021)
1	Pain	50	2644	52.88	7.926	Q1
2	Molecular Pain	45	1996	44.36	3.370	Q3
3	Journal of Neuroscience	42	4689	111.64	6.709	Q1
4	British Journal of Pharmacology	40	2329	58.23	9.473	Q1
5	Neuroscience	32	1408	44	3.708	Q3
6	European Journal of Pharmacology	28	1250	44.64	5.195	Q2
6	Scientific Reports	28	618	22.07	4.996	Q2
7	Journal of Pharmacology and Experimental Therapeutics	25	1871	74.84	4.441	Q2
7	Plos One	25	976	39.04	3.752	Q2
7	International Journal of Molecular Sciences	25	194	7.76	6.208	Q1

Table 4. Top 10 productive cited journals in TRPV1 channel and inflammation field.

Rank	Journal	Citation counts	Impact factors (2021)	JCI quartile (2021)
1	Nature	1123	69.504	Q1
2	Journal of Neuroscience	1047	6.709	Q1
3	Proceedings of the National Academy of Sciences of the United States of America (PNAS)	992	12.779	Q1
4	Pain	921	7.926	Q1
5	British Journal of Pharmacology	863	9.473	Q1
6	Journal of Biological Chemistry	822	5.486	Q2
7	Neuroscience	788	3.708	Q3
8	Neuron	775	18.688	Q1
9	Science	730	63.798	Q1
10	European Journal of Pharmacology	692	5.195	Q2

Figure 5. Analysis of authors and co-cited authors in TRPV1 channel and inflammation. Network map of authors (a) and cited authors (b) by CiteSpace.

Table 5. Top 10 authors of publications in TRPV1 channel and inflammation field.

Authors	Document accounts	Article with the highest citation	Citations
Lu-yuan Lee	18	Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat	88
Zsuzsanna Helyes	12	Evidence for the role of lipid rafts and sphingomyelin in Ca2±gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals	58
Pierangelo Geppetti	12	4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1	554
Peter W Reeh	12	The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6	73
Brian M Davis	9	TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous Nociceptors responding to heat	118
Janos Szolcsanyi	8	Evidence for the role of lipid rafts and sphingomyelin in Ca2±gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals	58
Juliano Ferreira	7	Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents	58
Narender R Gavva	7	Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans	350
Donna H Wang	7	Transient Receptor Potential Vanilloid Gene Deletion Exacerbates Inflammation and Atypical Cardiac Remodeling After Myocardial Infarction	60
Armen N Akopian	7	Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia	164

Table 6. Top 10 cited authors of publications in TRPV1 channel and inflammation field.

Rank	Cited authors	Citations
1	Michael J. Caterina	880
2	Makoto Tominaga	404
3	Arpad Szallasi	359
4	John B. Davis	299
5	Sven-Eric Jordt	231
6	Peter Holzer	207
7	Ru-Rong Ji	203
8	Diana M Bautista	197
9	Huai-Hu Chuang	175
10	Narender R Gavva	170

Figure 6. Analysis of co-cited references. (a) the density of co-cited references in TRPV1 channel and inflammation by VOSviewer; (b) the network map of co-cited references in TRPV1 channel and inflammation by CiteSpace; (c) Top 25 references with the strongest citation bursts in this research; (d) the timeline view of the 19 clusters.

Table 7. Top 10 references with citations in TRPV1 channel and inflammation field.

Rank	Title	First author	Journal	Publication year	Citations	DOI
1	Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor	Caterina MJ	Science	2000	71	10.1126/science.288.5464.306
2	Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia	Davis JB	Nature	2000	61	10.1038/35012076
3	TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents	Bautista DM	Cell	2006	60	10.1016/j.cell.2006.02.023
4	The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept	Szallasi A	Nat Rev Drug Discov	2007	56	10.1038/nrd2280
5	Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition	Chuang HH	Nature	2001	54	10.1038/35082088
6	p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia	Ji RR	Neuron	2002	50	10.1016/S0896–6273(02)00908-X
7	The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain	Walker KM	J Pharmacol Exp Ther	2003	48	10.1124/jpet.102.042010
8	4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1	Trevisani M	PNAS	2007	43	10.1073/pnas.0705923104
9	TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction	Kwan KY	Neuron	2006	40	10.1016/j.neuron.2006.03.042
9	The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway	Caterina MJ	ANNU REV NEUROSCI	2001	40	10.1146/annurev.neuro.24.1.487

Figure 7. Analysis of keywords and burst detection. The network map of keywords in TRPV1 channel and inflammation by Citespace (a) and VOSviewer (b); (c) the density of keywords in TRPV1 channel and inflammation by VOSviewer; (d) Cluster visualization of the keyword map; (e) the timeline view of the clusters; (f) Top 25 keywords with the strongest citation bursts.

Table 8. Top 20 keywords in terms of frequency in TRPV1 channel and inflammation field.

Rank	Keywords	Frequency	Rank	Keywords	Frequency
1	TRPV1 channel	858	11	nociception	122
2	inflammation	351	12	primary sensory neuron	117
3	dorsal root ganglion	279	13	TRPA1 ion channel	113
4	pain	238	14	hyperalgesia	111
5	calcitonin gene-related peptide	178	15	spinal cord	78
6	neurogenic inflammation	173	16	oxidative stress	74
7	substance p	163	17	protein kinase c	69
8	TRP channel	156	18	primary afferent neuron	68
9	capsaicin	125	19	thermal hyperalgesia	61
9	nerve growth factor	125	20	inflammatory pain	51

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.