Clinical and neonatal outcomes of intrauterine insemination with frozen donor sperm

Figures & data

Table 1. Maternal characteristics in the AIH and AID groups.

	AIH	AID	P value
Maternal age (years)	28.9 ± 3.3	26.9 ± 3.3	<0.0001
BMI	22.8 ± 3.4	21.6 ± 2.7	<0.0001
Duration of infertility (years)	3.4 ± 2.0	3.7 ± 2.5	0.313
Stimulation protocol
Natural cycle	24 (7.9)^a	79 (45.7)	<0.0001
Ovarian stimulation cycle	280 (92.1)	94 (54.3)
Endometrium thickness (mm)	10.2 ± 1.9	10.4 ± 1.7	0.199
Number of insemination per cycle
Once	47 (15.5)	20 (11.6)	0.239
Twice	257 (84.5)	153 (88.4)

^aValues in parenthesis are expressed in percentage.

BMI: Body mass index; AIH: artificial insemination by the husband; AID: artificial insemination by a donor.

Table 2. Clinical outcomes of singleton pregnancies.

	AIH	AID	P value
Number of clinical pregnancy	304	173
Number of ongoing pregnancy until delivery	264 (86.8)^a	153 (88.4)	0.613
Number of abortion	28 (9.2)	16 (9.2)	0.989
Number of early abortion	22 (7.2)	16 (9.2)	0.435
Number of late abortion	6 (2.0)	0	0.152
Number of ectopic pregnancy	10 (3.3)	3 (1.7)	0.477
Number of pregnancy complications	3 (1.0)	0	0.479
Number of termination of pregnancy	12 (3.9)	4 (2.3)	0.340

^aValues in parenthesis are expressed in percentage.

AIH: Artificial insemination by the husband; AID: artificial insemination by a donor.

Table 3. Neonatal characteristics of live births.

	AIH	AID	P value
Number of live births	262	153
Boys	122 (46.6)^a	76 (49.7)	0.541
Girls	140 (53.4)	77 (50.3)
Birthweight (g)	3384.3 ± 550.3	3507.6 ± 459.3	0.020
LBW (<2500 g)	12 (4.6)	1 (0.7)	0.054
Gestational age (weeks)	39.0 ± 1.8	39.3 ± 1.1	0.110
Prematurity (<37 weeks)	22 (8.4)	8 (5.2)	0.229

^aValues in parenthesis are expressed in percentage.

LBW: Low birth weight; AIH: artificial insemination by the husband; AID: artificial insemination by a donor.

Table 4. The association between maternal characteristics and the birthweight of live-born singletons by multiple linear regression analysis.

	Non-standardized coefficients		Standardized coefficients
Model	B	Standard error	Beta	t	Significance
Constant	2769.783	354.723		7.808	<0.0001
AID vs. AIH	146.923	63.563	0.136	2.311	0.021
Female age (years)	9.519	8.858	0.062	1.075	0.283
BMI	19.275	7.964	0.122	2.420	0.016
Duration of infertility	−25.914	13.235	−0.110	−1.958	0.051
Stimulation protocol (ovarian stimulation cycle vs. natural cycle)	−43.885	69.447	−0.036	−0.632	0.528
Endometrium thickness (mm)	−2.698	13.746	−0.010	−0.196	0.845
Number of insemination per cycle (twice vs. once)	69.838	75.435	0.046	0.926	0.355

BMI: Body mass index; AIH: artificial insemination by the husband; AID: artificial insemination by a donor.

Table 5. Stillbirths and fetal defects.

	AIH	AID
Number of stillbirths	2 (0.8)^a	0
Number of fetal defects	4 (1.5%)	1 (0.6)
Live births	3 (Atrial septal defect [2], hemangioma of the mouth [1])	0
Termination of pregnancy	1 (Cardiac dysplasia)	1 (Gastrointestinal dysplasia)

^aValues in parenthesis are expressed in percentage.

AIH: Artificial insemination by the husband; AID: artificial insemination by a donor.