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Research Paper

Thus spoke peptides: SARS-CoV-2 spike gene evolved in humans and then shortly in rats while the rest of its genome in horseshoe bats and then in treeshrews

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Pages 96-104 | Received 23 Feb 2022, Accepted 18 Mar 2022, Published online: 10 Apr 2022

Figures & data

Figure 1. Distances between SARS-CoV-2 pentapeptide vocabulary and pentapeptide vocabularies of the main clades of mammals.

The figure shows immunological T-distances (controlled for the size and richness of pentapeptide vocabulary of mammals) between listed mammal hosts and all proteins except spike (left) and spike protein (right) of the SARS-CoV-2 virus. The error bars show 95% confidence intervals.
Figure 1. Distances between SARS-CoV-2 pentapeptide vocabulary and pentapeptide vocabularies of the main clades of mammals.

Figure 2. Distances between SARS-CoV-2 hexapeptide vocabulary and hexapeptide vocabularies of the main clades of mammals.

For the legend see.
Figure 2. Distances between SARS-CoV-2 hexapeptide vocabulary and hexapeptide vocabularies of the main clades of mammals.

Figure 3. Probable origins of SARS-CoV-2 and RaTG13.

The “mosaic” origin of SARS-CoV-2 and RaTG13 revealed on the basis of pentapeptide and hexapeptide vocabularies. It is not possible to decide whether the plybasic furin clevage site was introduces into the S gene before or after its donor met the rodent host or even after the chimeric SARS-CoV-was formed by the recombination. The initial transmission of the donor of the spike gene from bats to humans (left) is only hypothetical and not supported by any peptide vocabularies data.
Figure 3. Probable origins of SARS-CoV-2 and RaTG13.
Supplemental material

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