Exploring Genetic Factors Involved in the Risk of Bruxism in Male Construction Workers

Figures & data

Table 1. Studied genes and genetic polymorphisms.

Gene symbol	Gene name	Chr	Reference sequence	Position	Base change	Global MAF^‡
ANKK1	Ankyrin repeat and kinase domain containing 1	11	rs1800497	Missense^#	CCT[C/T]^†GAC	0.325
DRD2	Dopamine Receptor D2	11	rs6275	Synonymous codon	CCA[C/T]^†GGT	0.473
			rs6276	UTR	GCC[A/G]^†GCC	0.466

^†ancestral allele; ^‡minor allele frequency. Database: http://www.ncbi.nlm.nih.gov/snp/. ^#Glu>Lys.

Table 2. Frequency of bruxism.

Parafunction		Frequency	Percent (%)
Bruxism (clench and/or grind)	No	90	79.65
	Yes	23	20.35
Clenching	No	95	84.07
	Yes	18	15.93
Grinding	No	97	85.84
	Yes	16	14.16

Table 3. Genotype distributions among groups.

Gene	Genotype	Bruxism (clench and/or grind)			Clenching			Grinding
		No n (%)	Yes n (%)	p	No n (%)	Yes n (%)	p	No n (%)	Yes n (%)	p
DRD2 (rs6275)	CC	11 (14.10)	2 (10.00)	.867	12 (14.63)	1 (6.25)	.579	12 (14.29)	1 (7.14)	.745
	CT	39 (50.00)	11 (55.00)		42 (51.22)	8 (50.00)		42 (50.00)	8 (57.14)
	TT	28 (35.90)	7 (35.00)		28 (34.15)	7 (43.75)		30 (35.71)	5 (35.71)
DRD2 (rs6276)	AA	13 (20.31)	4 (23.53)	.933	14 (20.90)	3 (21.43)	.882	15 (21.43)	2 (18.18)	.930
	AG	30 (46.88)	8 (47.06)		32 (47.76)	6 (42.86)		33 (47.14)	5 (45.45)
	GG	21 (32.81)	5 (29.41)		21 (31.34)	5 (35.71)		22 (31.43)	4 (36.36)
ANKK1 (rs1800497)	CC	5 (5.62)	1 (4.35)	.907	5 (5.32)	1 (5.56)	.958	6 (6.25)	0 (0.00)	.586
	CT	38 (45.70)	9 (39.13)		40 (42.55)	7 (38.89)		40 (41.67)	7 (43.75)
	TT	46 (51.69)	13 (56.52)		49 (52.13)	10 (55.56)		50 (52.08)	9 (56.25)

Table 4. Allelic distributions among groups.

Gene	Allele	Bruxism (clench and/or grind)			Clenching			Grinding
		No n (%)	Yes n (%)	p	No n (%)	Yes n (%)	p	No n (%)	Yes n (%)	p
DRD2 (rs6275)	C	61 (39.10)	15 (37.5)	.852	66 (40.24)	10 (31.25)	.339	54 (34.61)	10 (35.71)	.910
	T	95 (60.89)	25 (62.5)		98 (59.75)	22 (68.75)		102 (65.38)	18 (64.28)
DRD2 (rs6276)	A	56 (43.75)	16 (47.05)	.729	60 (44.77)	12 (42.85)	.852	63 (45)	9 (40.90)	.719
	G	72 (56.25)	18 (52.94)		74 (55.22)	16 (57.14)		77 (55)	13 (59.09)
ANKK1 (rs1800497)	C	48 (26.96)	11 (23.91)	.675	50 (26.59)	9 (25.0)	.842	52 (27.08)	7 (21.88)	.535
	T	130 (73.03)	35 (76.08)		138 (73.40)	27 (75.0)		140 (72.91)	25 (78.13)

Data Availability statement

The datasets generated and analyzed during this study are available from the corresponding author upon reasonable request.