Figures & data
Figure 1. Adherence to Macaca fascicularis intestinal explants. Sections of proximal colon from freshly euthanized cynomolgus monkeys were incubated with strain C227-11 (A), with HS (B) or with media alone for 3 hours (C) and then visualized by Scanning Electron Microscopy (SEM).Citation68 In panel (A), the arrow indicates dilation of the crypts. Scale bar is 100 µm.
Figure 2. Scanning Electron Microscopy of C227-11 and biofilm formation after 18 hours on glass cover slips. Arrow indicates aggregating bacteria and AAF/I fimbriae.
Figure 3. Model of the Pathogenesis of the O104:H4 outbreak strain. See text for explanation. Abbreviations: AAF/I; aggregative adherence fimbriae type I, pAA; virulence plasmid of C227-11, ESBL; extended-spectrum β-lactamase antibiotic resistance plasmid, AggR; AraC/XylS family activator, Aai; Type VI secretion system, Aat; dispersin translocator, Stx; Shiga Toxin, SigA; IgA protease-like homolog, Pic; Serine protease precursor, and SepA; Shigella extracellular protease.
