Figures & data
Figure 1. Activation of locus of enterocyte effacement (LEE) genes in enterohemorrhagic E. coli O157:H7. Outside the host, LEE genes are silenced by the global repressor H-NS. Once inside the host, different environmental stimuli and transcription factors partially activate LEE genes through induction of Ler expression (Ler antagonizes H-NS repression). Mechanosensation causes complete activation of LEE genes through the full induction of Ler in a GrlA - dependent manner. Transcriptional activators and repressors are shown by pointed and blunt arrows, respectively. Figure adapted from Kendall et al.Citation28
