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Gut Microbes Volume 11, 2020 - Issue 3
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Addendum

Can gut microbiota of men who have sex with men influence HIV transmission?

Sara L. Colemana Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
C. Preston Neffa Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
Sam X. Lia Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
Abigail J.S. Armstrongb Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAORCID Iconhttps://orcid.org/0000-0002-7677-8092View further author information
ORCID Icon,
Jennifer M. Schneidera Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
Sharon Sena Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
Blair Fennimorec Division of Gastroenterology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
Thomas B. Campbelld Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
,
Catherine A. Lozuponeb Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAView further author information
&
Brent E. Palmera Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USACorrespondence[email protected]
View further author information
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Pages 610-619 | Received 23 Sep 2019, Accepted 27 Nov 2019, Published online: 10 Feb 2020

Figures & data

Figure 1. Elevated CCR5 frequencies on total and activated CD4+ T cells in the rectosigmoid colon of MSM.

Figure 1. Elevated CCR5 frequencies on total and activated CD4+ T cells in the rectosigmoid colon of MSM.

Figure 2. The MSM immune profile, shaped by the MSM-associated microbiome, enhances HIV infection upon exposure due to elevated frequencies of cell phenotypes preferentially infected by HIV in the rectosigmoid colon. MSM have a Prevotella-rich microbiome with the presence of Erysipelotrichaceae family members not commonly found in the Bacteroides-rich MSW microbiome. The lamina propria immune environment of MSM contains higher frequencies of CCR5 on total and activated CD4+ T cells. In the peripheral blood, MSM have more CD8+ T cell activation and increased frequencies of CD103+ T cell homing to the gut.

Figure 2. The MSM immune profile, shaped by the MSM-associated microbiome, enhances HIV infection upon exposure due to elevated frequencies of cell phenotypes preferentially infected by HIV in the rectosigmoid colon. MSM have a Prevotella-rich microbiome with the presence of Erysipelotrichaceae family members not commonly found in the Bacteroides-rich MSW microbiome. The lamina propria immune environment of MSM contains higher frequencies of CCR5 on total and activated CD4+ T cells. In the peripheral blood, MSM have more CD8+ T cell activation and increased frequencies of CD103+ T cell homing to the gut.

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