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Gut Microbes Volume 11, 2020 - Issue 4
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Research Paper/Report

The microbiome modulating activity of bile acids

Yuan Tiana Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA;b CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, University of Chinese Academy of Sciences, Wuhan, P. R. ChinaORCID Iconhttps://orcid.org/0000-0001-6174-3359View further author information
ORCID Icon,
Wei Guia Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAView further author information
,
Imhoi Kooa Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAORCID Iconhttps://orcid.org/0000-0002-5816-0627View further author information
ORCID Icon,
Philip B. Smithc Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAView further author information
,
Erik L. Allmana Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAORCID Iconhttps://orcid.org/0000-0002-6560-0889View further author information
ORCID Icon,
Robert G. Nicholsa Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAView further author information
,
Bipin Rimala Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAORCID Iconhttps://orcid.org/0000-0001-6528-5156View further author information
ORCID Icon,
Jingwei Caia Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAView further author information
,
Qing Liua Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USAView further author information
&
Andrew D. Pattersona Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2073-0070View further author information
ORCID Icon show all
Pages 979-996 | Received 25 Oct 2019, Accepted 13 Feb 2020, Published online: 05 Mar 2020

Figures & data

Figure 1. Scheme for determining the antibacterial activity of bile acids in vivo and vitro.

Figure 1. Scheme for determining the antibacterial activity of bile acids in vivo and vitro.

Figure 2. The growth rate and physiological response of Bacteriodes fragilis and Ruminococcus bromii to bile acid exposure in vitro.

Figure 2. The growth rate and physiological response of Bacteriodes fragilis and Ruminococcus bromii to bile acid exposure in vitro.

Figure 3. UPLC-MS/MS-based metabolomics analysis of Ruminococcus bromii in response to bile acid exposure in vitro.

Figure 3. UPLC-MS/MS-based metabolomics analysis of Ruminococcus bromii in response to bile acid exposure in vitro.

Figure 4. The growth rate and UPLC-MS/MS-based metabolomics analysis of Bifidobacterium longum in response to bile acid exposure in vitro.

Figure 4. The growth rate and UPLC-MS/MS-based metabolomics analysis of Bifidobacterium longum in response to bile acid exposure in vitro.

Figure 5. The growth rate and physiological response of Clostridium scindens to bile acid exposure in vitro.

Figure 5. The growth rate and physiological response of Clostridium scindens to bile acid exposure in vitro.

Figure 6. The bacterial community and physiological response of isolated cecal bacteria to bile acid exposure in vitro.

Figure 6. The bacterial community and physiological response of isolated cecal bacteria to bile acid exposure in vitro.

Figure 7. 1H NMR-based metabolomics analysis of isolated cecal bacteria in response to bile acid exposure in vitro.

Figure 7. 1H NMR-based metabolomics analysis of isolated cecal bacteria in response to bile acid exposure in vitro.

Figure 8. UPLC-MS/MS-based metabolomics analysis of isolated cecal bacteria in response to bile acid exposure in vitro.

Figure 8. UPLC-MS/MS-based metabolomics analysis of isolated cecal bacteria in response to bile acid exposure in vitro.

Figure 9. The response of cecal bacteria to bile acid exposure in vivo.

Figure 9. The response of cecal bacteria to bile acid exposure in vivo.
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