https://orcid.org/0000-0002-9256-8191
Figures & data
Figure 1. Summary of relevant bacterial-fungal metabolic interactions discussed in this review. Bacteria and fungi generally interact through different forms of metabolic crosstalk in the human body. However, some metabolic interactions occur in specific organs and are associated with human health and disease onset. Studies on the bacterial-fungal metabolic interactions in respiratory airways mainly focus on the fungi A. fumigatus and C. albicans, and their distinct relationships with the bacterium P. aeruginosa, although these relationships involve several metabolic pathways.
Figure 2. The multiplicity of metabolic interactions between P. aeruginosa and C. albicans. Green arrows represent a metabolite-driven enhancement of growth and/or metabolite secretion. Red arrows represent a metabolitedriven inhibition of growth and/or metabolite secretion. Quorum-sensing and alcohol communication pathways cross-interact with each other, as seen with the role played by P. aeruginosa HSL in fungal ethanol-driven stimulation of bacterial trehalose production. Amino acids are hypothetically involved in P. aeruginosa/C. albicans communication; however, this hypothesis has not been studied yet.
