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Gut Microbes Volume 16, 2024 - Issue 1
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Review

Roles of microbiota in pancreatic cancer development and treatment

Mariana Santos Cruza II. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;b Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;c Hamburg Center for Translational Immunology (HCTI), Hamburg, GermanyView further author information
,
Joseph Tintelnota II. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;c Hamburg Center for Translational Immunology (HCTI), Hamburg, GermanyCorrespondence[email protected]
View further author information
&
Nicola Gaglianib Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;c Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany;d I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyView further author information
Article: 2320280 | Received 06 Nov 2023, Accepted 14 Feb 2024, Published online: 27 Feb 2024

Figures & data

Figure 1. Roles of the microbiota in PDAC. The microbiota plays a role in PDAC carcinogenesis via the modulation of the immune compartment composition in the tumor microenvironment or via the production of microbiota-derived metabolites. PDAC patients have unique oral, intestinal and intratumoral microbiota signatures and its characterization may be useful as clinical biomarkers of PDAC diagnosis and prognosis. Considering this, strategies modulating the composition of the microbiota have therapeutic potential in PDAC. MDSCs: myeloid-derived suppressor cells. TAMs: tumor-associated macrophages. SCFAs: short-chain fatty acids. BAs: bile acids. Created with BioRender.com.

Figure 1. Roles of the microbiota in PDAC. The microbiota plays a role in PDAC carcinogenesis via the modulation of the immune compartment composition in the tumor microenvironment or via the production of microbiota-derived metabolites. PDAC patients have unique oral, intestinal and intratumoral microbiota signatures and its characterization may be useful as clinical biomarkers of PDAC diagnosis and prognosis. Considering this, strategies modulating the composition of the microbiota have therapeutic potential in PDAC. MDSCs: myeloid-derived suppressor cells. TAMs: tumor-associated macrophages. SCFAs: short-chain fatty acids. BAs: bile acids. Created with BioRender.com.

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