Figures & data
FIGURE 1. Crosstalk between actomyosin contractility and microtubule acetylation. Actomyosin and microtubules regulate the rate of cell migration by controlling the assembly and disassembly of integrin-mediated adhesions. Typically, integrin-mediated adhesions are categorized as focal complexes, focal adhesions, or fibrillar adhesions. When cells are under high actomyosin contractility, there appears to be a low level of microtubule acetylation (panel A). However, when cells are under low actomyosin contractility, there appears to be an increase in the acetylation of microtubules and maturation of integrin-mediated adhesions to the fibrillar form (panel B).
![FIGURE 1. Crosstalk between actomyosin contractility and microtubule acetylation. Actomyosin and microtubules regulate the rate of cell migration by controlling the assembly and disassembly of integrin-mediated adhesions. Typically, integrin-mediated adhesions are categorized as focal complexes, focal adhesions, or fibrillar adhesions. When cells are under high actomyosin contractility, there appears to be a low level of microtubule acetylation (panel A). However, when cells are under low actomyosin contractility, there appears to be an increase in the acetylation of microtubules and maturation of integrin-mediated adhesions to the fibrillar form (panel B).](/cms/asset/05a672dc-2e1b-49fe-b25c-8fc5062f58d3/kbia_a_1171428_f0001_c.gif)
FIGURE 2. Actomyosin contractility and microtubule acetylation govern the levels of fibronectin and α5β1 integrins in developing salivary glands. Salivary glands explants infected with lentivirus expressing an acetyl-mimetic mutant of tubulin (HyperAcetylated MT; panel C) appear to have more fibronectin and α5β1 integrins compared to glands expressing the acetyl-null mutant of tubulin (HypoAcetylated MT; panel B). Although more characterizations are needed, fibronectin polymerizes into filaments and is depicted in fibrous form at the basement membrane for clarity.
![FIGURE 2. Actomyosin contractility and microtubule acetylation govern the levels of fibronectin and α5β1 integrins in developing salivary glands. Salivary glands explants infected with lentivirus expressing an acetyl-mimetic mutant of tubulin (HyperAcetylated MT; panel C) appear to have more fibronectin and α5β1 integrins compared to glands expressing the acetyl-null mutant of tubulin (HypoAcetylated MT; panel B). Although more characterizations are needed, fibronectin polymerizes into filaments and is depicted in fibrous form at the basement membrane for clarity.](/cms/asset/fa4768fa-e922-4cd6-a64f-4bfde6c58490/kbia_a_1171428_f0002_c.gif)