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Nucleus Volume 6, 2015 - Issue 1
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The ubiquitous transcription factor CTCF promotes lineage-specific epigenomic remodeling and establishment of transcriptional networks driving cell differentiation

Julie Dubois-ChevalierInserm UMR U1011; Lille, France;Université de Lille; Lille, France;Institut Pasteur de Lille; Lille, France;European Genomic Institute for Diabetes (EGID), FR3508; Lille, France
,
Bart StaelsInserm UMR U1011; Lille, France;Université de Lille; Lille, France;Institut Pasteur de Lille; Lille, France;European Genomic Institute for Diabetes (EGID), FR3508; Lille, France
,
Philippe LefebvreInserm UMR U1011; Lille, France;Université de Lille; Lille, France;Institut Pasteur de Lille; Lille, France;European Genomic Institute for Diabetes (EGID), FR3508; Lille, France
&
Jérôme EeckhouteInserm UMR U1011; Lille, France;Université de Lille; Lille, France;Institut Pasteur de Lille; Lille, France;European Genomic Institute for Diabetes (EGID), FR3508; Lille, FranceCorrespondence[email protected]
Pages 15-18 | Received 06 Oct 2014, Accepted 18 Nov 2014, Published online: 04 Mar 2015

Figures & data

Figure 1. Involvement of ubiquitous TFs in the transcriptional regulation of cell differentiation. The main concepts discussed in the manuscript are summarized (see text for details). The absence or presence of histone modifications that characterize active enhancers (H3K4me1 and H3K27ac) is indicated together with DNA methylation (5mC) and DNA hydroxymethylation (5hmC). H3K4me1, monomethylation of histone H3 lysine 4; H3K27ac, acetylation of histone H3 lysine 27; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine.

Figure 1. Involvement of ubiquitous TFs in the transcriptional regulation of cell differentiation. The main concepts discussed in the manuscript are summarized (see text for details). The absence or presence of histone modifications that characterize active enhancers (H3K4me1 and H3K27ac) is indicated together with DNA methylation (5mC) and DNA hydroxymethylation (5hmC). H3K4me1, monomethylation of histone H3 lysine 4; H3K27ac, acetylation of histone H3 lysine 27; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine.

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