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Chromatin architecture underpinning transcription elongation

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Pages 1-8 | Received 09 May 2016, Accepted 07 Jun 2016, Published online: 05 Aug 2016

Figures & data

Figure 1. Architectural model of transcription elongation. In the model depicted, the DNA template moves relative to the pol2 complex that is established via enhancer- and promoter-bound transcription factors. This leads to protrusion of the newly transcribed DNA placing the enhancer and promoter in dynamic proximity with the template. On an absolute scale, whether the pol2 complex is fixed or whether it contributes to the relative movement between it and the template will ultimately be resolved by live cell imaging.

Figure 1. Architectural model of transcription elongation. In the model depicted, the DNA template moves relative to the pol2 complex that is established via enhancer- and promoter-bound transcription factors. This leads to protrusion of the newly transcribed DNA placing the enhancer and promoter in dynamic proximity with the template. On an absolute scale, whether the pol2 complex is fixed or whether it contributes to the relative movement between it and the template will ultimately be resolved by live cell imaging.

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