Figures & data
Figure 1. Histone modification as a means for communication and cross-regulation between different DNA regulated processes. (A) Histone modifications can serve as a platform for communication between the different DNA-dependent processes: DNA-related processes are coupled to changes in histone modifications and histone turnover. These include the eviction and assembly of histones during DNA replication and transcription, the modification of histones, in preparation and during these processes, and the recruitment of specific proteins (e.g. DNA repair machinery following DNA damage). We propose that through the platform of histone modifications, one process can pass information needed for the regulation of other DNA-dependent processes. (B) H3K56ac as a signal of communication between DNA replication and transcription: During replication, newly synthesized histones are acetylated by Rtt109 and Asf1 on H3K56. These histones are incorporated in replicated loci, allowing the discrimination between replicated and non-replicated regions. In turn, this information deposited by a replication-associated process, allows tuning expression to buffer changes in DNA dosage.
![Figure 1. Histone modification as a means for communication and cross-regulation between different DNA regulated processes. (A) Histone modifications can serve as a platform for communication between the different DNA-dependent processes: DNA-related processes are coupled to changes in histone modifications and histone turnover. These include the eviction and assembly of histones during DNA replication and transcription, the modification of histones, in preparation and during these processes, and the recruitment of specific proteins (e.g. DNA repair machinery following DNA damage). We propose that through the platform of histone modifications, one process can pass information needed for the regulation of other DNA-dependent processes. (B) H3K56ac as a signal of communication between DNA replication and transcription: During replication, newly synthesized histones are acetylated by Rtt109 and Asf1 on H3K56. These histones are incorporated in replicated loci, allowing the discrimination between replicated and non-replicated regions. In turn, this information deposited by a replication-associated process, allows tuning expression to buffer changes in DNA dosage.](/cms/asset/4dbeba8e-6f5c-4779-8649-0d25457aa052/kncl_a_1216743_f0001_oc.gif)