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Research PAPER

The perinucleolar compartment: structure, function, and utility in anti-cancer drug development

ORCID Icon & ORCID Icon
Article: 2306777 | Received 25 Sep 2023, Accepted 12 Jan 2024, Published online: 27 Jan 2024

Figures & data

Figure 1. Immunofluorescence images showing PNCs detected by a PTBP1-specific antibody (green) and nucleoli labeled with an anti-UBF antibody (red). Nuclei are visualized by DAPI staining (blue) scale bar, 5 μm.

Figure 1. Immunofluorescence images showing PNCs detected by a PTBP1-specific antibody (green) and nucleoli labeled with an anti-UBF antibody (red). Nuclei are visualized by DAPI staining (blue) scale bar, 5 μm.

Figure 2. Using the PNC as a readout in metastasis-selective compound screens.

Figure 2. Using the PNC as a readout in metastasis-selective compound screens.

Figure 3. Possible PNC functions in cancer cells.

Figure 3. Possible PNC functions in cancer cells.