Advanced search
Publication Cover
Dialogues in Clinical Neuroscience Volume 14, 2012 - Issue 3
Submit an article Journal homepage
384
Views
18
CrossRef citations to date
0
Altmetric
Translational Research

Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders

lluminando el camino: los estudios genéticos identifican mecanismos del neurodesarrollo en el autismo y los trastornos relacionados

Une voie éclairée: des études génétiques mettent en évidence les mécanismes neurodéveloppementaux dans l'autisme et dans des troubles liés

Matthew F. Pescosolidoa Department of Molecular Biology, Cell Biology and Biochemistry; and Institute for Brain Science; Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital and Department of Psychiatry and Human Behavior
,
Unikora Yangb Department of Molecular Biology, Cell Biology and Biochemistry; and Institute for Brain Science;
,
Mark Sabbaghb Department of Molecular Biology, Cell Biology and Biochemistry; and Institute for Brain Science;
&
Eric M. Morrowc Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital and Department of Psychiatry and Human Behavior; Brown University Medical School, Providence, Rhode Island, USACorrespondence[email protected]
Pages 239-252 | Published online: 01 Apr 2022

Figures & data

Figure 1. Timeline of human brain development. This figure represents a schematized conceptualization of the steps during human brain development. Time in weeks post-conception and then postnatal years are shown along the horizontal axis. Birth and puberty and age at which cerebral cortex begins to thin are shown. The onset, peak, and end of different stages of neurodevelopment are depicted in color-coded fashion as shown in the associated table. “Days” in the figure refer to embryonic days. “Years” refer to postnatal years. The timing of the human stages is approximately based on refs 6, 117, 118, 119.
Figure 1. Timeline of human brain development. This figure represents a schematized conceptualization of the steps during human brain development. Time in weeks post-conception and then postnatal years are shown along the horizontal axis. Birth and puberty and age at which cerebral cortex begins to thin are shown. The onset, peak, and end of different stages of neurodevelopment are depicted in color-coded fashion as shown in the associated table. “Days” in the figure refer to embryonic days. “Years” refer to postnatal years. The timing of the human stages is approximately based on refs 6, 117, 118, 119.

TABLE I. Molecular mechanisms and genes implicated in autism map onto a limited number of steps in neurodevelopment. *We refer readers to https://gene.sfari.org/autdb/Welcome.do for references regarding each gene mutation.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.