An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line

Figures & data

Figure 1. Human Corneal cell construct.

Table 1. Size distribution and Zeta Potential measurement of SLN-NAC.

Formulation	Average particle Size (nm) ± SD (n = 3)	Zeta Potential ± SD (n = 3)
SLN-NAC	75 ± 10	−22.1 ± 1

Figure 2. TEM micrographs of SLN-NAC.

Table 2. Percentage of drug loading SLN and the percentage of entrapment of drug in the SLN-NAC.

Formulation	Drug Loading %	Entrapment efficiency %
SLN-NAC	8 ± 0.65	86.16 ± 2.4

Figure 3. in-vitro release profile of SLN-NAC.

Figure 4. FTIR spectra of NAC and SLN-NAC.

Figure 5. Impedance profiles of Normal HENC cells, SLN-NAC treated HENC cells, Free NAC treated HENC cells and cataract induced HENC cells.

Figure 6. Percentage of SLN-NAC and NAC permeation in human corneal construct.

Figure 7. (A) Drug permeation of SLN-NAC; (B) Drug permeation of NAC in human corneal construct.

Figure 8. Corneal hydration % of SLN-NAC treated and Free NAC treated Cornea.

Figure 9. Cytotoxicity of PBS (control), NAC and SLN-NAC.