The role of tacstd-2 level in hepatitis C patients (controlled clinical research)

Figures & data

Table 1. Comparison of viral load and Tacstd-2 concentration in Hepatitis C positive patients by viral genotype

	Genotype 1b (n = 49)	Non-genotype 1b (1a,2,3,4) (n = 12)	p
HCV RNA	171x10^4 ± 604x10^4	286x10^4 ± 623 x10^4	0.60
Tacstd-2	708 ± 492	613 ± 382	0.55

HCV-RNA: Hepatitis C virus ribonucleic acid; Tacstd-2: Tumor-associated calcium signal transducer 2.

Mean ± SD was given at regular intervals.

Table 2. Comparison of laboratory parameters of Hepatitis C patients with controls

	Hepatitis C patients (n = 61)	Controls (n = 29)	p
Tacstd-2 (ng/U)	691.2 ± 473.3	524.1 ± 290.1	0.043
AST (IU/L)	43.0 (8–337)	31.5 ± 8.0	0.002
ALT (IU/L)	38 (6–971)	35.1 ± 9.1	0.26
ALP (IU/L)	108.6 ± 72.6	73.0 ± 29.1	0.201
GGT (U/L)	87.1 ± 179.2	39.8 ± 22.0	0.091
Hb (g/dL)	12.61 ± 1.68	13.24 ± 2.83	0.31

Tacstd-2: Tumor-associated calcium signal transducer 2; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase; Hb:Hemoglobin

Mean ± SD was given at regular intervals and median (min-max) at irregular intervals.

Table 3. Comparison of Hepatitis C patients with and without cirrhosis

	Non-cirrhotic patients (n = 41)	Cirrhotic patients (n = 20)	p
Tacstd-2 (ng/U)	679.3 ± 447.4	715.5 ± 333.9	0.78
AST (IU/L)	60.11 ± 61.9	56.6 ± 24.4	0.82
ALT (IU/L)	94.91 ± 172.4	73.5 ± 26.4	0.23
ALP (IU/L)	90.1 ± 43.8	146.6 ± 102.6	0.012
GGT (U/L)	49.8 ± 42.1	167.1 ± 303.7	0.042
Hb (g/dL)	13.09 ± 1.8	11.55 ± 1.8	0.02
HCV–RNA (copies/mL)	150X10^3 (472-322x10^5)	289 x10^3 (3474-167x10^4	0.85
Platelets (/μL)	192900 ± 75167	98680 ± 60920	<0.001
INR	1.02 ± 0.19	1.25 ± 0.14	<0.001
Bilirubin (mg/dL)	0.64 ± 0.45	1.54 ± 0.94	<0.001

Tacstd-2: Tumor-associated calcium signal transducer 2; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase; Hb: Hemoglobin; Hep C-RNA Hepatitis C viral RNA; INR – International normalized ratio.

Mean ± SD was given at regular intervals and median (min-max) at irregular intervals.

Table 4. The correlations between tumor-associated calcium-binding transducer-2 and liver function tests, hematologic parameters, and age

Tacstd-2	AST	ALT	ALP	GGT	INR	Bil	Hg	Platelets	Age
r	−0.311	−0.293	−0.272	−0.268	−0.168	−0.261	−0.008	−0.008	−0.19
p	0.023	0.033	0.067	0.079	0.328	0.095	0.128	0.957	0.138

Tacstd-2: Tumor-associated calcium signal transducer 2; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase; Hb: Hemoglobin; Hep C-RNA Hepatitis C viral RNA; INR – International normalized ratio; Bil: Bilirubin; r: Correlation Coefficient.

Figure 1. Correlation relationship between Tacstd-2 and Alanine Aminotransferase in Hepatitis C group. Alt: Alanine aminotransferase, Tacstd-2: tumor-associated calcium signal transducer 2.

Figure 2. Correlation relationship between Tacstd-2 and Aspartate Aminotransferase in Hepatitis C group. Ast: Aspartate aminotransferase, Tacstd-2: tumor-associated calcium signal transducer 2.

Table 5. Comparison of Hepatitis C patients with Group A (Tumor-associated calcium signal transducer-2 < 500 ng/U) and Group B (Tumor-associated calcium signal transducer-2 > 500 ng/U) according to laboratory parameters

	Group A	Group B	p
AST (IU/L)	74.4 ± 65.0	38.2 ± 18.9	0.08
ALT (IU/L)	113.1 ± 188.3	33.7 ± 17.6	0.032
GGT(IU/L)	61.4 ± 45.1	131.5 ± 282.4	0.32
ALP (IU/L)	109.0 ± 57.1	110.6 ± 93.4	0.25
INR	1.16 ± 0.2	1.05 ± 0.2	0.11
Bilirubin(mg/dL)	1.1 ± 0.8	0.8 ± 0.81	0.29

Group A: Tumor-associated calcium signal transducer 2 < 500 ng/U, Group B: Tumor-associated calcium signal transducer 2 > 500 ng/U

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase, SD: Standart Deviation, GGT: Gamma glutamyl transpeptidase; INR: International normalized ratio.

Mean ± SD was given at regular intervals and median (min-max) at irregular intervals.

Table 6. Hematological and biochemical parameters affecting Tacstd-2 according to linear regression analysis (Backward method)

	B	SE	t	p	OR (95% CI)	Adjusted R square
ALT Hemoglobin	−3.73 –126.94	1.96 40.79	−1.903 –3.10	0.076 0.007	−7.90–0.45 –213,28- −39,39	0.44

Dependent variable was Tacstd-2 and independent variables in the regression model were GGT, AST, ALP, INR, albumin, hemoglobin, and platelets.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase, GGT: Gamma glutamyl transpeptidase; INR: International normalized ratio.